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FP5

WOOD-RISK Résumé de rapport

Project ID: QLK4-CT-2000-00573
Financé au titre de: FP5-LIFE QUALITY
Pays: Denmark

Genotoxicity, generation of reactive oxygen species (ROS), and inflammatory responses induced by wood dusts in human lung cells in vitro

The in vitro studies carried out with human lung epithelial cells show that exposure to wood dust resulted in DNA strand-breaks in four out of seven wood dusts examined. DNA strand breaks occurred before the inflammation had reached its maximum, which suggests that wood dusts themselves may have genotoxic potential. The distribution of the species that caused strand breaks, and those that did not, was randomly distributed between the hardwood and softwoods. Cytokine responses were induced by all seven species. The lowest and highest responses were found among the hardwoods, and the responses of the softwoods were between the extremes found among hardwoods.

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Håkan WALLIN, (Professor)
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