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Genotoxicity, generation of reactive oxygen species (ROS), and inflammatory responses induced by wood dusts in human lung cells in vitro

The in vitro studies carried out with human lung epithelial cells show that exposure to wood dust resulted in DNA strand-breaks in four out of seven wood dusts examined. DNA strand breaks occurred before the inflammation had reached its maximum, which suggests that wood dusts themselves may have genotoxic potential. The distribution of the species that caused strand breaks, and those that did not, was randomly distributed between the hardwood and softwoods. Cytokine responses were induced by all seven species. The lowest and highest responses were found among the hardwoods, and the responses of the softwoods were between the extremes found among hardwoods.

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Reported by

NATIONAL INSTITUTE OF OCCUPATIONAL HEALTH
Lersí Parkalle 105
2100 KOEPENHAGEN
Denmark