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Project ID: IST-2001-39112
Finanziato nell'ambito di: FP5-IST
Paese: Israel

A preparative scheme for controlled modification of gold nanoparticles using reversible binding to a polymeric solid support

We have developed a preparative scheme for controlled modification of gold nanoparticles (NPs) by using reversible binding to a polymeric solid support, potentially useful for immobilization of specific receptors for target analytes.

Reversible binding of Au nanoparticles (NPs) to a polymeric solid support was demonstrated by using boronic-derivatized resins and the specific reaction of diol molecules with boronic acid. The versatility of boronic acid chemistry offers a powerful tool for NP manipulation, while the polymer support provides the preparative element.

In the present case the boronic acid/diol chemistry was exploited for controlled transfer of linker molecules from the resin to the capping layer of the NPs, to obtain free, linker-modified Au NPs. The reversibility of boronic acid chemistry was used for rebinding linker-bearing NPs to a boronic resin by means of the diol linker molecule, thereby establishing 1) the presence of linker molecules on the modified NPs, and 2) an effective affinity separation scheme. This enabled selective extraction and separation of NPs from a mixed solution, as well as convenient NP recovery.

The preparative schemes presented here may be useful in various aspects of NP technology. These include specialized NP modification, controlled NP release, NP separation and purification, chemical reactions on immobilized NPs, and others.

Reported by

THE WEIZMANN INSTITUTE OF SCIENCE
HERZEL STREET 2
76100 REHOVOT
Israel