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Project ID: IST-2001-34718
Finanziato nell'ambito di: FP5-IST
Paese: Germany

Patterned insect neurons

To induce neurite guiding in insect cell cultures cell attractive biomolecules were printed using micro-contact printing (µCP) onto a cell repellent background in order to create a high contrast between the two areas.

In cooperation with the Deutsche Wollforschungsinstitut at the RWTH Aachen we developed a new procedure to bind concanavaline A (con A) covalently on a background of so-called star PEG (polyethyleneglycol). PEG is known to hinder protein binding and therefore it should reduce cell adhesion. As a result cricket neurons adhered only on con A areas and neurite outgrowth was restricted to areas modified with con A.


Andreas OFFENHAUSSER, (Head of Institute)
Tel.: +49-246-1612330
Fax: +49-246-1618733