Community Research and Development Information Service - CORDIS

Mechanism of retinoid induction of tumor-selective TRAIL signaling

Role of TRAIL in apoptosis induced by retinoids and rexinoids. TRAIL as effector of different signalling pathways during the induction of cell death. Role of TRAIL inducibility in cancer cells. Tumour specific cell death.

Investigation of alternative rexinoid-based pathways of apoptosis involving TRAIL induction. Molecular investigation of retinoid resistance in leukemias.

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Hinrich GRONEMEYER, (Research Director)
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