Forschungs- & Entwicklungsinformationsdienst der Gemeinschaft - CORDIS

DNA vaccination with plasmid IL-2 induces suppressor function in regulatory T cells

Suppressor T cells are a promising tool for therapies of immunologic disorders like allergies or autoimmune diseases. We could identify IL-2 and particularly plasmid DNA vaccination using pIL-2 to strongly activate suppressor function in CD25+ Foxp3 regulatory T cells (Treg).

Following gene-gun vaccination with IL-2 Treg were able to suppress antigen specific T cell proliferation in vivo following vaccination with an antigen-coding plasmid. The suppression depends on TGF-b and IL-10. and can be transferred by regulatory T cells.

This strategy to activate Treg suppressor activity might be helpful for the treatment or prevention of allergies or autoimmune disease.

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Alexander SCHEFFOLD, (Head of Unit of Immunomodulation)
Tel.: +49-3028460700
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