Service Communautaire d'Information sur la Recherche et le Développement - CORDIS

FP5

ALLDNAVAC Résumé de rapport

Project ID: QLK3-CT-2002-02026
Financé au titre de: FP5-LIFE QUALITY
Pays: Germany

DNA vaccination with plasmid IL-2 induces suppressor function in regulatory T cells

Suppressor T cells are a promising tool for therapies of immunologic disorders like allergies or autoimmune diseases. We could identify IL-2 and particularly plasmid DNA vaccination using pIL-2 to strongly activate suppressor function in CD25+ Foxp3 regulatory T cells (Treg).

Following gene-gun vaccination with IL-2 Treg were able to suppress antigen specific T cell proliferation in vivo following vaccination with an antigen-coding plasmid. The suppression depends on TGF-b and IL-10. and can be transferred by regulatory T cells.

This strategy to activate Treg suppressor activity might be helpful for the treatment or prevention of allergies or autoimmune disease.

Contact

Alexander SCHEFFOLD, (Head of Unit of Immunomodulation)
Tél.: +49-3028460700
Fax: +49-3028460603
E-mail