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Documentation of the presence of Ovalbumin-specific IgE-secreting plasma cells in bone marrow of allergic mice

A mouse model of allergy to Ovalbumin has been established as described (see result 38144). By use of the Elispot technique (see result 38145), we could detect high numbers of Ovalbumin-specific IgE-secreting plasma cells in bone marrow of allergic mice, as soon as d4-d7 after the last i.t. administration of antigen.

The early presence of antigen-specific IgE- secreting plasma cells in the bone marrow, i.e. a primary lymphoid organ, is a new finding that could be important for the design of new strategy of vaccination against allergic diseases and could be a factor influencing the efficiency of vaccines.

Reported by

Consiglio Nazionale Ricerche
Istituto di Genetica A. Buzzati Traverso, Via P. Castellino, 111
75010 Napoli
Italy
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