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ALLDNAVAC Informe resumido

Project ID: QLK3-CT-2002-02026
Financiado con arreglo a: FP5-LIFE QUALITY
País: Italy

pCMVIC80DerP1 DNA immunization plasmid containing the gene encoding for the dust mite allergen of Dermatophagoides pteridissinus (DerP1)

Plasmid pCMVIC80Derp1 is an in-house developed construct containing the Der P1 gene, to be used for cell transfection and in vivo immunization experiments.

In this plasmid, DerP1 is cloned as fusion to the leader sequence of the murine MHC class II invariant chain, in order to target Derp1 expression into MHC class II pathway.

The plasmid is able to express the encoded antigen in vitro transfected cells. This construct is particularly suitable for immunogenicity studies in naïve and allergic murine models.

The plasmid is also suitable for studies aimed at evaluating antigen processing and presentation and APCs activation upon DNA uptake. The application can be disseminated as further R&D.

Reported by

Novartis Vaccines and Diagnostics Srl (ex Chiron)
Via Fiorentina, 1
75010 Siena
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