Community Research and Development Information Service - CORDIS

FP5

MENDOS Report Summary

Project ID: QLK4-CT-2002-02323
Funded under: FP5-LIFE QUALITY
Country: Germany

Highly sensitive optical transducer based on interferometry

UTU has successfully built up an Integrated Optical Mach-Zehnder setup, which has been tested with well-investigated antibody reactions. It is possible to produce a multi-analyte interferometric sensor and to evaluate those results with the help of Artificial Neural Networks.

Due to the lack of MIPs delivering specific binding signals in water, SPR (Surface Plasmon Resonance) and RIfS (Reflectometric Interference Spectroscopy) were used as alternative optical method to test the MIPs supplied by TUM and LUND in organic solvents. Specific, time-resolved and reproducible binding signals were detected with the MIPs imprinted against atrazine.

Within the data evaluation part a chemometric model could be developed which is in principle able to predict endocrine disrupting potential from multi-analyte sensor signals, but could not be tested with MIPs, again because of the lack of MIPs which could be measured in water with the Mach-Zehnder.

Contact

Günter GAUGLITZ, (Head of Institute)
Tel.: +49-707129-76927
Fax: +49-707129-5490
E-mail
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