Servicio de Información Comunitario sobre Investigación y Desarrollo - CORDIS


HOLOTC, EARLY B12 MA Informe resumido

Project ID: QLK3-CT-2002-01775
Financiado con arreglo a: FP5-LIFE QUALITY
País: Denmark

Analytical performance

The performance of the commercially available HoloTC RIA was evaluated. Total imprecision was 10% or less. No inter-laboratory deviations were observed in the range 10 to 200 pmol/L.

The assay works well but has certain limitations:
Such as the time and technical skill needed to perform the assay, the use of radioactivity, and the large sample volume needed, which severely limits the possibility to re-test samples.

On the basis of these results the commercial partner intensified development of a more user-friendly non-isotopic method requiring less sample and adaptable to automatic clinical instruments. This assay, HoloTC AxSYM became available toward the end of the project.


Ebba NEXO, (Professor)
Tel.: +45-89-493083
Fax: +45-89-493060
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