Servicio de Información Comunitario sobre Investigación y Desarrollo - CORDIS

Analytical performance

The performance of the commercially available HoloTC RIA was evaluated. Total imprecision was 10% or less. No inter-laboratory deviations were observed in the range 10 to 200 pmol/L.

The assay works well but has certain limitations:
Such as the time and technical skill needed to perform the assay, the use of radioactivity, and the large sample volume needed, which severely limits the possibility to re-test samples.

On the basis of these results the commercial partner intensified development of a more user-friendly non-isotopic method requiring less sample and adaptable to automatic clinical instruments. This assay, HoloTC AxSYM became available toward the end of the project.

Reported by

Aarhus University Hospital
Norrebrogade 44
8000 AARHUS C
Denmark
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