Service Communautaire d'Information sur la Recherche et le Développement - CORDIS

WP 1: General Food Restriction (GFR)

To understand the nutritional and mechanistic basis of the alterations of ?-cell development observed after maternal food restriction in rat (50% of ad libitum intake during the last week of pregnancy until the end of lactation and ad libitum feeding from weaning onwards).

In the GFR model, the low beta cell mass appears to result from defective neogenesis of islets from precursor cells rather than to lower islet cell proliferation. We demonstrated a high glucocorticoid plasma level that alters the generation of pancreatic endocrine cells and favours the development of the exocrine component of the pancreas. This was revealed by changes in the expression of genes specifically involved in the pancreatic development.

We suspected that the action of glucocorticoids was linked to binding of the glucocorticoid receptor to a region of the promoter of a gene which codes for the most important transcription factor governing the development of the  cells, i.e. Pdx-1. Contrary to what was found in case of Protein Restriction (WP2), the plasma and islet amino acids level were almost normal.


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