Community Research and Development Information Service - CORDIS

FP5

NUTRIX Report Summary

Project ID: QLK1-CT-2000-00083
Funded under: FP5-LIFE QUALITY
Country: Belgium

WP 2: Protein restriction (PR)

To understand the mechanisms responsible for the reduced ?-cell mass observed in early life in the offspring of mother fed on a protein restricted diet (PR, 8% instead of 20% during the entire pregnancy and until weaning).

Maternal PR that also reduces the  cell mass, was associated with a normal glucocorticoid level but with alteration in the plasma amino acid levels. PR altered islet endocrine pancreas development by decreasing the cell multiplication and islet vascularisation, and increasing the "programmed cell death" or apoptosis. It also rendered the  cell more prone to be destroyed by toxic aggression like those playing a role in the pathogenesis of type 1 diabetes. This remained at adulthood even if a normal diet was given from weaning.

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Claude REMACLE
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