Community Research and Development Information Service - CORDIS

FP5

TARGETS FOR CANCER T Report Summary

Project ID: QLK3-CT-1999-00875
Funded under: FP5-LIFE QUALITY
Country: Estonia

p19Arf is required to mediate CD43 dependent p53 induction

The p53 protein induced by CD43 is transcriptionally active stimulating transcription from p53-responsive promoters. CD43 does not induce p53 in cells lacking ARF, but ARF expression in these cells restores the ability of CD43 to induce p53. CD43 is also able to induce endogeonous ARF in p53 negative cells. Thus, the p53 response could be activated due to the possible mitogenic stimuli caused by CD43 expression.

CD43 over-expression in human cancer cells hindered the detection of the Fas death receptor on the cell surface and thereby helped to evade Fas-mediated apoptosis. When both p53 and ARF proteins were present, CD43 over-expression activated p53 and suppressed colony formation due to induction of apoptosis. These observations suggest potential contribution of CD43 to tumour development by promoting cell growth and evading apoptosis.

Contact

Toivo MAIMETS, (Professor, Head of the Department of Cell Biology)
Tel.: +37-273-75028
Fax: +37-274-20286
E-mail
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