Servicio de Información Comunitario sobre Investigación y Desarrollo - CORDIS

p19Arf is required to mediate CD43 dependent p53 induction

The p53 protein induced by CD43 is transcriptionally active stimulating transcription from p53-responsive promoters. CD43 does not induce p53 in cells lacking ARF, but ARF expression in these cells restores the ability of CD43 to induce p53. CD43 is also able to induce endogeonous ARF in p53 negative cells. Thus, the p53 response could be activated due to the possible mitogenic stimuli caused by CD43 expression.

CD43 over-expression in human cancer cells hindered the detection of the Fas death receptor on the cell surface and thereby helped to evade Fas-mediated apoptosis. When both p53 and ARF proteins were present, CD43 over-expression activated p53 and suppressed colony formation due to induction of apoptosis. These observations suggest potential contribution of CD43 to tumour development by promoting cell growth and evading apoptosis.

Reported by

UNIVERSITY OF TARTU
INSTITUTE OF MOLECULAR AND CELL BIOLOGY, 23 RIIA STR.
51010 TARTU
Estonia
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