Forschungs- & Entwicklungsinformationsdienst der Gemeinschaft - CORDIS


MVAC Berichtzusammenfassung

Project ID: QLK2-CT-2002-00617
Gefördert unter: FP5-LIFE QUALITY
Land: France

Development of functional eukaryotic expression plasmid encoding ovine IFNg and IL4 cytokines for use as immune modulators

The genes encoding ovine IFNg and IL4 were cloned and ligated into a eukaryotic plasmid expression vector that expresses the IFNg and IL4 proteins in mammalian cells both in vitro and in vivo. These plasmid vectors can be used as immunomodulators in vaccine studies (as in this project) using plasmid DNA vaccination methods. Small ruminant IFNg and IL4 genes have been used previously in other vaccine studies and represent pre-existing knowledge.

The end users of the information are other scientists working in the field of SRLV control, or working with other lentiviruses, or working with other plasmid DNA vaccines, or in the general area of vaccines and immune responses, or in the general area of lentivirology.

Commercial companies may be interested in the plasmid reagents, but the market for these is likely to be restricted to the small ruminant research community and therefore very small.


Marie SUZAN, (Scientist in charge)
Tel.: +33-4-91324375
Fax: +33-4-91387772
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