Community Research and Development Information Service - CORDIS

Mucosal DNA vaccination with env but not gag reduces MVV provirus load in blood but not in tissues

Animal immunized mucosally with env but not gag showed significantly reduced pro-virus loads in blood but not tissues as measured by real-time PCR. The immunising method utilised plasmid DNA complexed to polyethyleneimine. This method gives transgene expression in sheep lungs in other studies, and therefore immunological responses were expected locally in tissues. The results suggest that virus dissemination from the lung tissue was reduced by env immunization.

The end users of the information are other scientists working in the field of SRLV control, or working with other lentiviruses, or working with other plasmid DNA vaccines, or in the general area of vaccines and immune responses, or in the general area of lentivirology.

Commercial companies may be interested in the information though they are unlikely to consider commercialisation.


Francesco TOLARI, (Head of Unit)
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Fax: +39-050-540644
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