Forschungs- & Entwicklungsinformationsdienst der Gemeinschaft - CORDIS

Mucosal DNA vaccination with gag but not env reduces the severity of lesions

Animals immunised mucosally with EV1 gag gene showed a lower frequency of moderate/severe lesions in the lungs and MLN. This protective effect was significantly weaker than that observed with systemic immunisation with the gag gene. No protective effect was observed with the env gene and inclusion of IFNg in the priming and first booster did not enhance the protective effect.

The end users of the information are other scientists working in the field of SRLV control, or working with other lentiviruses, or working with other plasmid DNA vaccines, or in the general area of vaccines and immune responses, or in the general area of lentivirology.

Commercial companies may be interested in the information though they are unlikely to consider commercialisation.

Reported by

UNIVERSIDAD DE ZARAGOZA
MIGUEL SERVET 177
50013 ZARAGOZA
Spain
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