Servizio Comunitario di Informazione in materia di Ricerca e Sviluppo - CORDIS

3-dimensional structures of proteinases and proteinase/ inhibitor complexes

The crystal structures of the catalytic domain of the human matrix metalloproteinase 16 (MMP-16 alias MT3-MMP), of human full-length proMMP-1, of the complex between the catalytic domain of MMP-13 and the bovine tissue inhibitor of metallo proteinases 2 (TIMP-2), and of the truncated human MMP-9 catalytic domain in complex with various synthetic inhibitors have been determined.

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