Community Research and Development Information Service - CORDIS

Discovery that intermittent over-exposure to UVB radiation is effective in induction of nevi, possible precursor lesions of melanomas

Major results ('deliverables') of our present activity in the MAUVE project on induction of melanocytic hyperplasia (moles/nevi) and tumors (melanomas):

- 1 - "Intermittent overexposure to UVB radiation is effective in induction of nevi, possible precursor lesions of melanomas". (an important experimental substantiation of epidemiologic finding that irregular exposure leading to episodes of severe sunburns increases melanoma risk presumably by stimulating growth of melanocytic lesions in general)

Notes:
Sub - 1 - In contrast to expectation, overexposure of wild-type mice produced higher numbers of nevi than overexposure of XPA mice with a defect in repair of UVB-induced DNA damage.

Reported by

Leiden University Medical Centre
Postal Zone S2P
2300 RC Leiden
Netherlands
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