Wspólnotowy Serwis Informacyjny Badan i Rozwoju - CORDIS

Chimeric and deleted C strain mutant viruses

Vaccine candidates Flc9 (BVDVII E2 exchanged in C-strain), Flc11 (BVDVII Erns exchanged in C-strain) and vaccine strains C-strain (Flc2) and a trans-complemented Erns deletion mutant (Flc23) derived from the C-strain were studied in animal experiments. PBMCs of these vaccinated animals were used in CTL assays. It was concluded that the Erns, E2 and NS3-4B* proteins were targets for the cellular immune system. The observed cellular immune response was short in time and differences between the vaccine strains were relatively small.

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