Community Research and Development Information Service - CORDIS

Characterization of a ovarian aquaporins

1. A novel subfamily of molecular water channels in teleosts, related to mammalian aquaporin-1(AQP1), named AQP1o, was discovered and characterized. These channels are highly expressed in the ovary of marine fish.
2. The sub-cellular localization of AQP1o in gilthead seabream oocyte was elucidated, demonstrating its role during hydration of the oocyte that occurs during oocyte maturation.
3. Amino acid domains located in the C-termini of gilthead seabream AQP1o involved in the regulation of the trafficking of the proteins into the plasma membrane of the oocyte were identified.
4. Protocols were developed for the induction of ovulation in vitro of gilthead seanream and zebrafish ovarian follicles.

Reported by

IRTA
LAB IRTA-ICM, CMIMA-CSIC, PASEIG MARITIM 37-49
08003 BARCELONA
Spain
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