Servizio Comunitario di Informazione in materia di Ricerca e Sviluppo - CORDIS

FP6

SPIROTENUIPESINES Sintesi della relazione

Project ID: 40386
Finanziato nell'ambito di: FP6-MOBILITY
Paese: United Kingdom

Final Activity Report Summary - SPIROTENUIPESINES (Total Synthesis of the Potent Neurotrophic Factors Spirotenuipesine A and B)

The researcher has initiated the work on the biomimetic total synthesis of the neurotrophic factor 11-O-debenzoyltashironin by collecting all the necessary background information and the relevant literature, she has consulted with senior members of the group and her supervisor to discuss novel ideas and use the previous group knowledge on the topic. The supervisor has been available on a daily basis to offer guidance, consultation and discussion of the progression of the work.

This work has provided a great platform to explore novel methodologies and investigate the chirality transfer in domino Diels-Alder processes. The syntheses of the target natural compound in both enantiopure forms and their analogues has been completed as planned in the first year of the fellowship and in the following period the researcher has liaised with a team of biologists who are screening the activity of the compounds in vitro. She has planned and suggested structural modifications to improve the activity of the compounds under the guidance of her supervisor.

Reported by

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
CAMBRIDGE
United Kingdom
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