Community Research and Development Information Service - CORDIS

  • European Commission
  • CORDIS
  • Projects and Results
  • Final Report Summary - EMBIC (The control of embryo implantation: studies of gene expression, protein profiles / functions at the utero embryonic level: cellular and molecular developmental events)
FP6

EMBIC Report Summary

Project ID: 512040
Funded under: FP6-LIFESCIHEALTH
Country: France

Final Report Summary - EMBIC (The control of embryo implantation: studies of gene expression, protein profiles / functions at the utero embryonic level: cellular and molecular developmental events)

The understanding of the molecular and cellular mechanisms that contribute to the successful implantation of the foetus in the maternal uterus is of increasing relevance in the European population, since the rate of female fertility decreases as a result of the delayed decision to pregnancy. Knowledge of these mechanisms could contribute to the further development of assisted reproduction techniques such as In vitro fertilisation (IVF) and Intro cytoplasmatic sperm injection (ICSI) and the medical treatment of women in order to increase the rates of successful pregnancies. Each cycle of IVF or ICSI intervention is linked with a high financial effort (EUR 3 000 - 5 000) that leads only in 30 % of cases to a successful implantation. The alternative choice of transferring more than one embryo at each cycle results often in multiple pregnancies.

Female sterility is increasing in Europe and the success rate of assisted reproductive technologies stalls at present around 25 % - IVF - and 27 % -ICSI. Understanding the cause(s) of such infertility and its increase is therefore of prime importance.

EMBIC has created in cooperation with an SME an European virtual laboratory to understand 'the implantation window', the proper formation of a functional decidua basalis and the intensive tissue remodelling which it requires in the uterus, and the de novo organogenesis on the foetal side (placenta formation), and to begin to develop specific diagnosis and therapeutic tools tailored to each patient according to the dysregulation causing her infertility.

Many of EMBIC fields were concerned by a major, if not mandatory, role of the (innate) immune system in implantation, such as cytokines at the interface, NK cells and implantation, complement and implantation, Pentraxin, the now cloned progesterone induced blocking factor (PIBF), etc. and of course MHC and implantation.

Ultimate goals were the selection of those (the) embryo(s) which will successfully implant; diagnosis and treatment of local perturbation of the uterine immune network which cause sterility. The work has spin offs for pre-eclampsia as well as endometriosis.

Related information

Contact

Gérard CHAOUAT, (Professor)
Tel.: +33-145374450
Fax: +33-146327993
E-mail
Follow us on: RSS Facebook Twitter YouTube Managed by the EU Publications Office Top