Community Research and Development Information Service - CORDIS

Humanised biomaterials

A French company developed a new type of implant, suitable for replacement or repair of human tissues such as bones and cartilages. The colonisation of porous biomaterials with autologous cells provides the implants with unique characteristics in terms of biocompatility, duration and adaptation to the patient.
Humanised biomaterials
Implants have been widely used in order to support or replace defected human tissues such as bones and cartilages. A large variety of processes and a huge number of materials are used in order for biocompatibility to be achieved. The implants that are currently available provide a good degree of biocompatiliby and/or promote tissue regeneration. However, there is always the risk of rejection and/or infection and additionally many of these implants need to be replaced after a period of ten to fifteen years.

A French company invented a pioneering way of producing biocompatible materials that incorporate monocytes derived cells or macrophages from the patients (autologous) by using advanced biotechnology techniques. According to this process, the autologous cells relevant to the tissue under replacement or repair undergo special treatment and then colonise porous biocompatible materials.

The resulting implants comprise three very important characteristics. Firstly, they allow better physiological interaction between the prostheses and the host cell body. Secondly, the lifespan of the prostheses is expanded. Finally, due to the growth factors that are secreted, they allow the growth and renewal of the surrounding cells and tissues as well as neovascularisation and reconstituting of blood microcapillaries around the grafted biomaterial. The ultimate result is humanised biocompatible implants that are custom made for each individual patient.

The unique characteristics of these implants in terms of biocompatility, duration and adaptation to the patient, make them suitable to meet the needs of orthopaedic, dental, maxillofacial and other surgical fields creating improved medical results.
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