Community Research and Development Information Service - CORDIS

Opthalmic solution prolongs pharmaceutical effect

A solution that prolongs the activity of pharmaceutical treatments instilled in the eyes has been invented by a French research team. Due to this solution, treatments applied to the eye can be active for a longer period of time without being affected by the cleaning effect of the lachrymal liquids.
Opthalmic solution prolongs pharmaceutical effect
Tears in the eyes do not always mean that something bad has happened. On the contrary, in most cases tears appear in the eyes as a protective mechanism against liquids, dust, or other objects that can possibly irritate them. This reaction is autonomous and cannot be controlled consciously. Even when we drop intentionally something into our eyes, the above reaction is activated and tears appear in order to clean the eye.

Instillation of drug solution drops in the eye is a common medical method for many eye infections. Although the drug’s effectiveness is proportional to the time that it is applied to the eye, the eyes protective reflex tends to remove the drug and function as an obstacle to treatment. A research team in the Louis Pasteur University focused its research activities on finding ways that extend the availability of drugs applied to the eye. This research resulted in a solution that prolongs the activity of drugs after their application to the eye.

This solution can be used in two different ways. Firstly in the form of a pure solution, given that artificial tears could alleviate symptoms of the dry eye syndrome. Alternatively it can be mixed either with drugs for treatment of eye infections or with active substances intended for an ocular examination. What is also important is that the solution does not irritate the eye.

The fact that the bioavailiability of the drugs on the eye is prolonged does not only increase the effectiveness of the drugs, but also reduces the required drug dosage and provides the patient with faster, better and more effective treatment.
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