Community Research and Development Information Service - CORDIS

Improving solubility of cyclodextrins-complexes

Cyclodextrin is a chemical compound with a wide range of potential applications that vary from water-soluble pharmaceuticals and cosmetics to herbicides and pesticides. In order to enhance the soluble properties of cyclodextrin-based chemicals, a research group developed a new process for its synthesis.
Improving solubility of cyclodextrins-complexes
Cyclodextrins consist of glucose units found in a three-dimensional arrangement that enables these substances to form inclusion complexes with various organic compounds. In addition, they may form complex small molecules that are not readily absorbed in water while they remain soluble. Depending on the number of glucose units they are typed as alpha-, beta-, and gamma cyclodextrins.

Through a highly specialised reaction, bacterial-derived amylolytic enzymes degrade starch and using a suitable organic solvent, which forms an insoluble complex with the cyclodextrin, the cyclodextrin is isolated. Until now, there have been many difficulties with the selective chemical functionality of cyclodextrins at the primary hydroxyls rim. These have been successfully encountered by a recent research work that developed a highly specialised process to include a reagent.

More specifically, this is a simple one-step process that uses cheap precursors and may result in b-cyclodextrin complexes of a yield as high as 50%. Thereby, a versatile linker, capable of absorbing water and used to graft a variety of organic derivatives onto the cyclodextrin core may enhance the functionality of these systems. Consequently, the solubility of cyclodextrin-based drugs, such as the anticancer agents of the taxane family may significantly increase.

The improved solubility properties of any chemical or organic agent are considered as very important features for developing effective pharmaceutical technologies. Furthermore, the patented process may also be used for developing targeted delivery systems and research tools in protein-carbohydrate interaction.
Record Number: 81049 / Last updated on: 2005-09-18
Domain: Biology, Medicine