Community Research and Development Information Service - CORDIS

New technology for monitoring bone healing

The assessment of the effect of novel pharmaceuticals on bone healing within a preclinical setting can often be unreliable and expensive. Research developments from Spain's Andalusia region, however, could soon provide scientists with a highly reproducible, cost-efficient method of evaluating bone fracture healing.
New technology for monitoring bone healing
Researchers have devised a complete system for the evaluation of fracture healing in rats. The method comprises two stages. The first part involves the induction of a standard middiaphyseal fracture in the rat femur. The process has been shown to be highly reproducible with a very low variance rate. The second stage includes the mechanical tests for assessing the strength of the healed bone.

The tests involve the application of specific levels of torsion to the bone at low speed using newly developed equipment. This novel equipment includes a highly sensitive sensor, able to detect low range forces and thus evaluate the progress of healing process in the bone. The approach allows for the application of the technology under a variety of settings.

The method has been repeatedly tested with success and the data show it to be highly reproducible and cost-effective. The main use of such a technology would be during the preclinical testing of novel fracture healing pharmaceutical products. It therefore meets the needs of pharmaceutical companies active in that field.
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