Community Research and Development Information Service - CORDIS

Enhancing animal testing capabilities

Pharmaceutical development depends upon a critical stage of animal testing, at the early stages of the development process. Creating proper animal models of human disease, suitable for testing purposes is a key requisite for success at this stage of the process.
Enhancing animal testing capabilities
Although challenging to create for various pathological states, reliable animal models of human central nervous system (CNS) diseases have proven to be particularly elusive. A Spanish research group however, has overcome a number of technical difficulties to arrive at a novel technology combining different animal models. The technology allows for the testing of the neurotoxicological effects of chemical agents in the short- and long-term.

Researchers have developed accurate models of anxiety, impulsivity/hyperactivity, reward and memory among others. For the first time, substances can be tested using all these models concurrently and thus pinpoint specific alterations in particular CNS systems. The use of the models allows for the construction of a complete neurotoxicological profile of tested substances, which would be invaluable as part of an ongoing development process and neural risk evaluation for new commercial compounds.

The developers of the technology are seeking partners to further enhance their technology and other kinds of collaboration could also be discussed. These results could be of particular interest to research institutions, diagnostics as well as pharmaceutical companies. A laboratory prototype is ready for demonstration and testing purposes.
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