Community Research and Development Information Service - CORDIS

New technologies for localised drug delivery

Mode of administration of pharmaceutical agents is a crucial determinant of their effectiveness. Loss of activity can often be directly attributed to breakdown mechanisms carried out in the stomach or the patient's blood.
New technologies for localised drug delivery
In an effort to overcome obstacles posed by specific modes of administration, researchers are seeking new ways of localised delivery. The University Louis Pasteur, Strasbourg is pursuing a research programme investigating the potential of novel solid oral dosage forms. The aim is to succeed in creating new formulations that release the medication in specific locales.

This innovative technology focuses on the delivery of medications in the last part of the gastrointestinal tract, the colon. For cases when localised activity is required, delivery in specific parts of the body is preferred. The University Louis Pasteur researchers used an existing oral dosage form, which they modified accordingly with the use of appropriate excipients.

The combination of new ingredients, allows the dosage form to pass through the top part of the gastrointestinal tract intact and arrive at the colon. The drug is then released following the interplay of enzymatic and pH breakdown of the solid formulation in the colon. The University is keen to commercially exploit this technology, which can find application in the field of pharmaceutics and diagnostics.

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Record Number: 82202 / Last updated on: 2005-11-16
Domain: Biology, Medicine