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EU-US WORKSHOP — Result In Brief

Project ID: 13079
Country: Netherlands

Enhancing collaboration in DNA damage research

Recent research in the area of DNA damage has revealed strong interplays between specific steps in principal defence pathways. This new development offers more information when compared to cellular compartmental studies of responses to DNA damage.
Enhancing collaboration in DNA damage research
To advance understanding of related processes, the cell should be seen as a large network of protein-protein and protein-DNA interactions responding systematically to DNA damage. As such, researchers investigating various DNA damage response pathways are now embracing approaches whereby global measurements of gene expression and the proteome are combined with genome-wide screening of sensitivity mutants.

This affords an integrated view of how cells respond to and protect themselves against damaging agents. Also, the integration of genome-wide measurements allows specific models of response networks to be developed, which can be further refined and tested for enhanced mechanistic understanding.

The 'Workshop on "Systems biology of DNA-damage-induced stress responses''' (EU-US workshop) project co-financed a workshop to develop better collaboration between researchers in the EU and the United States. The focus of the partly EU-funded project was on systems biology analysis of the major pathways in DNA damage response. The project worked to improve on harmonising protocols, integrating databases and increasing communication among scientists from both the EU and the United States.

A total of 31 lectures were presented and 27 posters were on display during the workshop, with a number of posters being selected for further discussion in a special session. During the workshop's last lecture, the speaker gave a summary and integrated all workshop information. After the workshop, the conference organising committee met to plan future activities.

The flow of know-how towards EU participants, of which 30 % were female, was reported to be very useful from an educational as well as a research standpoint. Moreover, two articles summarising the scientific outcomes of the workshop were accepted for publication in leading international journals.

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