Community Research and Development Information Service - CORDIS

FP7

IDEA Result In Brief

Project ID: 241642
Funded under: FP7-HEALTH
Country: Switzerland

Parasitic worms and poverty-related diseases

Nearly one in four patients with tuberculosis (TB), malaria or HIV has parasitic worm (helminth) infections. African and European scientists joined forces to elucidate how worm infections affect the immune responses.
Parasitic worms and poverty-related diseases
Moreover, there is a wide geographic overlap in occurrence between worms and HIV, TB and malaria. The EU-supported project IDEA has been studying these connections for four years.

Partners from six European and five African countries are involved in the project. The objectives of IDEA are to understand how the presence of worm infections affect immune responses specific to HIV, TB and malaria. The effects of parasitic worms on the clinical progression of these diseases are also under study.

The IDEA Central Database was established which unifies demographic, clinical and parasitological data and allows for centralised analysis. Meta-analysis of data obtained from HIV-TB- and malaria patients' cohorts from different sites is constantly underway.

Innate, or immediate immune response elicited by worm infections has been characterised. The scientists have determined whether the worm-induced innate immune response modulates the innate and adaptive immune response to HIV, TB and malaria antigens. Preliminary results were obtained regarding immunological interplay between helminth infections and HIV- and TB-specific T cell responses.

The effects of worm infections and anti-worm treatment on incidence, clinical presentation and immune responses against worms, as well as HIV, TB and malaria have been analysed. To determine the effect of worm-infections on vaccine-induced immune responses, the researchers have started vaccine trials for HIV, TB and malaria.

The IDEA research programme has made a substantial contribution to sustained and integrated research in sub-Saharan Africa. In addition, the project will ultimately contribute to the development of new successful therapies and vaccines.

Related information

Keywords

Parasiticworm, poverty-related disease, HIV, malaria, tuberculosis, vaccine
Record Number: 89935 / Last updated on: 2012-12-11
Domain: Biology, Medicine
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