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Early development of ovarian follicles - determination of the timing of menopause
Start date:2001-01-01
End date:2003-12-31
Project Acronym:OVAGE
Project status:Completed
Coordinator
| Organization name:ERASMUS UNIVERSITEIT ROTTERDAM | |
| Administrative contact | Address |
|
Name:Henk |
FACULTY OF MEDICINE AND HEALTH SCIENCES INSTITUTE OF ENDOCRINOLOGY AND REPRODUCTION PO Box 1738 50,Dr. Molewaterplein 50 3015 GE ROTTERDAM NEDERLAND Region:WEST-NEDERLAND ZUID-HOLLAND Groot-Rijnmond |
| Tel:+31-10-4081766 | |
| Fax:+31-10-4089090 | |
| E-mail: | |
| URL: | Organization Type:Education |
Description
Objective:
BACKGROUND: Menopause is a milestone in the ageing process in women, and the cessation of secretion of ovarian estrogens after menopause has a major impact on healthy ageing of women and their quality of life. One of the main determinants of the timing of menopause is the efficiency of the use of the primordial follicle stock. AIM: the determination of the role of anti-mullein hormone (AMH), growth and differentiation factor-9 and -9B (GDF9, GDF9B) in primordial follicle loss. OBJECTIVES and EXPECTED RESULTS:
(1) the development of large-scale production of AMH and GDF919B and of specific and sensitive assays to determine AMH and GDF9/9B in biological samples;
(2) the investigation of the role of AMH and GDF9/9B in early follicular development in women and in mice;
(3) the identification of regulated target genes of AMH and GDF9/9B in developing follicles.
Achievements:
General information:
Project Details
Start date:2001-01-01
End date:2003-12-31
Duration:36 months
Project Reference:QLK6-CT-2000-00338
Project cost:1399489 EURO
Project Funding:1399489 EURO
Programme Acronym:
FP5-LIFE QUALITY
Programme type:Fifth Framework Programme
Subprogramme Area:Key action The Ageing Population and Disabilities
Contract type:Cost-sharing contracts
URL:
Subject index:Life Sciences, Medicine, Health, Social Aspects
Other participants
| Organization name:UNIVERSITY OF HELSINKI | |
| Administrative contact | Address |
|
Name:Raija |
HAARTMAN INSTITUTE DEPARTMENT OF BACTERIOLOGY AND IMMUNOLOGY P.O. Box 33 Haartmaninkatu 3 00014 HELSINKI SUOMI/FINLAND Region:MANNER-SUOMI UUSIMAA |
| Tel:+35-89-1911 | |
| Fax:+35-89-19123077 | |
| E-mail:Contact | |
| URL: | Organization Type:Education |
| Organization name:UNIVERSITY OF KUOPIO | |
| Administrative contact | Address |
|
Name:Petteri |
A I. VIRTANEN INSTITUTE, MOLECULAR MEDICINE PO Box 1627 2,Neulaniementie 2 70211 KUOPIO SUOMI/FINLAND Region:MANNER-SUOMI ITÄ-SUOMI Pohjois-Savo |
| Tel:+358-1-7162100 | |
| Fax:+358-1-7162131 | |
| E-mail:Contact | |
| URL: | Organization Type:Education,Other |
| Organization name:OXFORD BROOKES UNIVERSITY | |
| Administrative contact | Address |
|
Name:John |
SCHOOL OF BIOLOGICAL AND MOLECULAR SCIENCES Gipsy Lane OX3 0BP OXFORD/HEADINGTON UNITED KINGDOM Region:SOUTH EAST (UK) BERKSHIRE, BUCKINGHAMSHIRE, OXFORDSHIRE Oxfordshire |
| Tel:+44-18-65483401 | |
| Fax:+44-18-65484238 | |
| E-mail:Contact | |
| URL: | Organization Type:Education |
Record control number:54315
