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The fe65-app-x11 protein-protein interaction network: towards the generation of new molecular tools for alzheimer's disease diagnosis and therapy.
Start date:2000-01-01
End date:2003-07-01
Project Acronym:GRASPING ALZHEIMER
Project status:Completed
Coordinator
| Organization name:UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II | |
| Administrative contact | Address |
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Name:Concetta |
DIPARTIMENTO DI BIOCHIMICA E BIOTECNOLOGIE MEDICHE Via Sergio Pansini 5 80131 Napoli ITALIA Region:CAMPANIA Napoli |
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| URL: | Organization Type:Education |
Description
Objective:
European Union Alzheimer's disease (AD) and related dementias affect 5% of persons aged 65-70 years, rising to 20% in those aged 85 and over. The full costs of AD to EU nations are very high. Due to demographic changes within Europe, the prevalence of AD and costs to the EU are likely to increase dramatically over the next four decades. There are currently no effective therapies for AD. Deposition of amyloidal beta peptide (Abita) within the brains of AD patients is believed to be central to the pathogenesis of the disease. Abita is derived by proteolysis cleavage from the precursor protein. APP. Recently, two families pf proteins, the Fe65s and Axis, have been shown to bind to APP and significantly influence APP processing and Abita production. The purpose of this project is to understand further the mechanisms by witch Fee and X11a influence APP processing and Abita production in AD. Another objective of the project is to explore the relevance of a recently discovered phenomenon (molecular misreading) witch causes the accumulation in AD brains of aberrant proteins. This work will lead to the generation of new AD animal models and to relevant knowledge to design innovative therapeutic strategies and new diagnostic tools.
Achievements:
General information:
Project Details
Start date:2000-01-01
End date:2003-07-01
Duration:42 months
Project Reference:QLK6-CT-1999-02238
Project cost:1666059 EURO
Project Funding:1400000 EURO
Programme Acronym:
FP5-LIFE QUALITY
Programme type:Fifth Framework Programme
Subprogramme Area:Key action The Ageing Population and Disabilities
Contract type:Cost-sharing contracts
URL:
Subject index:Medicine, Health, Life Sciences, Social Aspects
Other participants
| Organization name:KING'S COLLEGE LONDON | |
| Administrative contact | Address |
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Name:Lorraine |
INSTITUTE OF PSYCHIATRY DEPARTMENT OF NEUROSCIENCE De Crespigny Park W8 7AH LONDON UNITED KINGDOM Region:SOUTH EAST (UK) GREATER LONDON |
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| URL: | Organization Type:Education,Other |
| Organization name:ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCE | |
| Administrative contact | Address |
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Name:Dick |
NETHERLANDS INSTITUTE FOR BRAIN RESEARCH P.B. 19121 Meibergdreef 33 1105 AZ AMSTERDAM NEDERLAND Region:WEST-NEDERLAND NOORD-HOLLAND Groot-Amsterdam |
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| URL: | Organization Type:Research,Other |
Record control number:52676
