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High frequency stimulation of the subthalamic nucleus: a therapeutic approach to parkinson' s disease
Start date:2000-02-01
End date:2003-08-01
Project Acronym:STN AND PARKINSONISM
Project status:Completed
Coordinator
| Organization name:CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE | |
| Administrative contact | Address |
|
Name:Etienne |
UPR 9013 - LABORATOIRE DE NEUROBIOLOGIE CELLULAIRE ET FONCTIONNELLE Chemin Joseph Aiguier 31 13402 MARSEILLE FRANCE Region:MÉDITERRANÉE PROVENCE-ALPES-CÔTE D'AZUR Bouches-du-Rhône |
| Tel: | |
| Fax:+45-44-806010 | |
| E-mail: | |
| URL: | Organization Type:Research |
Description
Objective:
Parkinson's disease (PD) is a neurodegenerative illness with high prevalence and long course characterized by severe motor and cognitive impairments. Clinical trials have recently shown that chronic high frequency stimulation (HFS) of sub thalamic nucleus (STN) alleviates Parkinson Ian motor symptoms and elodea-induced complications at advanced stages of PD. However, little is known about the functional mechanisms of this new therapeutically tool, its long-term motor effects and consequences on cognitive functions. The aim of this project is thus to address these issues. Behavioural consequences of STN HFS will be specified in terms of motor and cognitive functions in PD patients and in animal models. Biochemical and cellular events underlying the behavioural effects of STN HFS and neuropath logical factors that may govern its efficacy will be investigated in animal models. The results are expected to have major socio-economic impacts by improving indication of STN HFS in the course of PD.
Achievements:
General information:
Project Details
Start date:2000-02-01
End date:2003-08-01
Duration:42 months
Project Reference:QLK6-CT-1999-02173
Project cost:1651628 EURO
Project Funding:898789 EURO
Programme Acronym:
FP5-LIFE QUALITY
Programme type:Fifth Framework Programme
Subprogramme Area:Key action The Ageing Population and Disabilities
Contract type:Cost-sharing contracts
URL:
Subject index:Life Sciences, Social Aspects, Medicine, Health
Other participants
| Organization name:THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE | |
| Administrative contact | Address |
|
Name:Michael |
Trinity Lane, The Old Schools, CB2 1TN CAMBRIDGE UNITED KINGDOM Region:EAST ANGLIA Cambridgeshire |
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| Fax: | |
| E-mail: | |
| URL: | Organization Type:Education,Other |
| Organization name:INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE | |
| Administrative contact | Address |
|
Name:Claude |
U 318 - NEUROBIOLOGIQUE PRÉCLINIQUE ADR 5 - Rhône-Alpes, Auvergne, Bourg. Univ. J.Fo 38043 GRENOBLE FRANCE Region:CENTRE-EST RHÔNE-ALPES Isère |
| Tel: | |
| Fax:+30-2610997848 | |
| E-mail: | |
| URL: | Organization Type:Research |
| Organization name:HUMBOLDT-UNIVERSITAET BERLIN | |
| Administrative contact | Address |
|
Name:Cornelius |
UNTER DEN LINDEN 9 10099 BERLIN DEUTSCHLAND Region:BERLIN Berlin Berlin |
| Tel: | |
| Fax: | |
| E-mail: | |
| URL: | Organization Type:Education |
Record control number:52698
