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European consortium on neutralising antibodies using gp41

Start date:2008-01-01

End date:2013-12-31

Project Acronym:EURONEUT-41

Project status:Execution

Coordinator

Organization name:SANOFI PASTEUR SA
Administrative contact	Address
Name:Delphine JULLIEN (Mrs.)	Avenue Pont Pasteur, 2 LYON FRANCE Region:CENTRE-EST RHÔNE-ALPES Rhône
Tel:+33-437-375601
Fax:+33-437-379495
E-mail:Contact
URL:	Organization Type:Industry

Description

Objective: There is now an increasingly solid body of scientific evidence which demonstrates that the binding of small molecular weight compounds, peptides and antibodies (Abs) to fusion-intermediate conformations of gp41 leads to an inhibition of HIV cell entry. The principal aim of this project is to exploit this information by establishing a platform where gp41-derived vaccine candidates will be designed to elicit neutralising Abs. Several families of immunogens which mimic gp41 in its fusion intermediate conformations are already available and others will be designed using modelisation approaches.

Candidates will be submitted to a thorough biophysical characterisation followed by a preclinical development in order to identify the most promising for clinical evaluation. A crucial selection parameter is the capacity of antigens to elicit neutralising Abs using internationally standardized assays. Since sexual transmission accounts for more than 90% of HIV infection, the capacity of Abs to inhibit infection at the mucosal level will also be determined.

Achievements:

General information:

Project Details

Start date:2008-01-01

End date:2013-12-31

Duration:72 months

Project Reference:201038

Project cost:15922033 EURO

Project Funding:11966082 EURO

Programme Acronym: FP7-HEALTH

Programme type:Seventh Framework Programme

Subprogramme Area:New HIV Vaccines inducing broadly-reactive neutralising antibodies

Contract type:Large-scale integrating project

URL:

Subject index:Life Sciences, Medicine, Health

Other Indexes:gp41fusion-intermediate,gp41 hybrid proteins,neutralising antibody,systemic and mucosal immunity

Results for this Project

Periodic Report Summary - EURONEUT-41 (European consortium on neutralising antibodies using gp41)	23/07/2012
Periodic Report Summary - EURONEUT-41 (European consortium on neutralising antibodies using gp41)	21/09/2011

Documents for this Project

Periodic Report - EURONEUT-41 (European consortium on neutralising antibodies using gp41)	23/07/2012
Periodic Report - EURONEUT-41 (European consortium on neutralising antibodies using gp41)	21/09/2011

Other participants

Organization name:POLYMUN SCIENTIFIC IMMUNBIOLOGISCHE FORSHUNGS GMBH
Administrative contact	Address
Name:Dietmar KATINGER (Dr)	DONAUSTRASSE 99 KLOSTERNEUBURG ÖSTERREICH Region:OSTÖSTERREICH NIEDERÖSTERREICH Wiener Umland/Nordteil
Tel:+43-1360066557
Fax:+43-13697615
E-mail:Contact
URL:http://www.polymun.com	Organization Type:

Organization name:QUEEN'S UNIVERSITY BELFAST
Administrative contact	Address
Name:Colleen SPENCE (Ms.)	University Road BELFAST UNITED KINGDOM Region:NORTHERN IRELAND
Tel:+44-2890976650
Fax:+44-2890975431
E-mail:Contact
URL:http://www.qub.ac.uk	Organization Type:Education

Organization name:ST GEORGE'S HOSPITAL MEDICAL SCHOOL
Administrative contact	Address
Name:Susan MCPHEAT (Ms.)	Cranmer Terrace LONDON UNITED KINGDOM Region:SOUTH EAST (UK) GREATER LONDON
Tel:+44-2082666818
Fax:+44-2087253426
E-mail:Contact
URL:http://www.sghms.ac.uk	Organization Type:Education

Organization name:COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Administrative contact	Address
Name:Etienne GARDERET (Mr)	RUE LEBLANC 25 PARIS 15 FRANCE Region:ÎLE DE FRANCE Ile de France Paris
Tel:+33-146549789
Fax:+33-146549180
E-mail:Contact
URL:http://www.cea.fr	Organization Type:

Organization name:GENEART AG
Administrative contact	Address
Name:Frank NOTKA (Dr)	Josef-Engert-Strasse 9 REGENSBURG DEUTSCHLAND Region:BAYERN OBERPFALZ Regensburg, Landkreis
Tel:+49-94194276645
Fax:+49-94194276711
E-mail:Contact
URL:http://www.geneart.de	Organization Type:

Organization name:PX'THERAPEUTICS
Administrative contact	Address
Name:Delphine COLOMBET (Dr)	15, rue des Martyrs GRENOBLE FRANCE Region:CENTRE-EST RHÔNE-ALPES Isère
Tel:+33-438023650
Fax:+33-476961038
E-mail:Contact
URL:	Organization Type:

Organization name:IM PROJET (SUISSE) SARL
Administrative contact	Address
Name:Philippe REGIS (Mr)	RUE DE LA FONTENETTE 29 CAROUGE SCHWEIZ/SUISSE/SVIZZERA Region:
Tel:+33-623832663
Fax:+33-478880420
E-mail:Contact
URL:http://www.improjet.fr	Organization Type:

Organization name:ROYAL FREE HOSPITAL, ROYAL FREE HAMPSTEAD NHS TRUST
Administrative contact	Address
Name:Margaret JOHNSON (Professor)	Pond street LONDON UNITED KINGDOM Region:SOUTH EAST (UK) GREATER LONDON
Tel:+44-2078302775
Fax:+44-2078302730
E-mail:Contact
URL:http://www.royalfree.nhs.uk	Organization Type:

Organization name:BIONEER A/S
Administrative contact	Address
Name:Lars Hagsholm PEDERSEN (Dr)	KOGLE ALLE 2 HOERSHOLM DANMARK Region:DANMARK Danmark Frederiksborg amt
Tel:+45-45160444
Fax:+45-45160455
E-mail:Contact
URL:http://www.bioneer.dk	Organization Type:

Organization name:LES CENTRES GHESKIO
Administrative contact	Address
Name:Jean William PAPE (Dr)	33 BOULEVARD HARRY TRUMAN 15267 PORT-AU-PRINCE HAITI Region:
Tel:+509-2220031
Fax:+509-2239044
E-mail:Contact
URL:	Organization Type:

Organization name:ROBERT KOCH-INSTITUT
Administrative contact	Address
Name:Joachim DENNER (Dr)	Nordufer 20 BERLIN DEUTSCHLAND Region:BERLIN
Tel:+49-3045472800
Fax:+49-3045472801
E-mail:Contact
URL:http://www.rki.de	Organization Type:

Organization name:NEMZETI ELELMISZERLANC-BIZTONSAGI HIVATAL
Administrative contact	Address
Name:Gábor KULCSÁR (Dr)	Szállás utca BUDAPEST MAGYARORSZAG Region:KOZEP-MAGYARORSZAG Budapest
Tel:+36-14330827
Fax:+36-12622839
E-mail:Contact
URL:http://www.ivmp.gov.hu	Organization Type:

Organization name:UNIVERSIDAD DE GRANADA.
Administrative contact	Address
Name:José Antonio CARRILLO MIÑÁN (Mr)	C/ Cuesta del Hospicio S/N GRANADA ESPAÑA Region:SUR ANDALUCIA Granada
Tel:+34-958248024
Fax:+34-958240886
E-mail:Contact
URL:http://www.ugr.es	Organization Type:

Organization name:IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
Administrative contact	Address
Name:Tatjana PALALIC (Ms.)	Exhibition Road, South Kensington Campus LONDON UNITED KINGDOM Region:SOUTH EAST (UK) GREATER LONDON
Tel:+44-2075943866
Fax:
E-mail:Contact
URL:http://www.imperial.ac.uk	Organization Type:Education

Organization name:UNIVERSITE DE STRASBOURG
Administrative contact	Address
Name:Sandrine SCHOTT-CARRIERE (Ms.)	rue Blaise Pascal 4 1032 STRASBOURG FRANCE Region:EST ALSACE Bas-Rhin
Tel:+33-368851124
Fax:
E-mail:Contact
URL:http://www.unistra.fr	Organization Type:

Organization name:UNIVERSITY OF SURREY
Administrative contact	Address
Name:Maria SEGA-BUHALIS (Mrs)	Stag Hill GUILDFORD UNITED KINGDOM Region:SOUTH EAST (UK) SURREY, EAST-WEST SUSSEX Surrey
Tel:+44-1483683498
Fax:+44-1483683791
E-mail:Contact
URL:http://www.surrey.ac.uk	Organization Type:

Organization name:IM PROJET SAS
Administrative contact	Address
Name:Philippe REGIS (Mr)	PORTE DU GRAND LYON 6 NEYRON FRANCE Region:CENTRE-EST RHÔNE-ALPES Ain
Tel:+33-472013282
Fax:+33-478880420
E-mail:Contact
URL:	Organization Type:

Organization name:INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Administrative contact	Address
Name:Sonia ROBINET (Ms.)	101 Rue de Tolbiac PARIS FRANCE Region:ÎLE DE FRANCE Ile de France Paris
Tel:+33-388108636
Fax:+33-388108175
E-mail:Contact
URL:http://www.inserm.fr	Organization Type:Education

Record control number:87833

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