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No pain during infancy by adapting off-patent medicines
Start date:2008-10-01
End date:2013-09-30
Project Acronym:NEOOPIOID
Project status:Execution
Coordinator
| Organization name:KAROLINSKA INSTITUTET | |
| Administrative contact | Address |
|
Name:Thomas |
Nobels Vag 5 STOCKHOLM SVERIGE Region:SVERIGE STOCKHOLM |
| Tel:+46-852488400 | |
| Fax:+46-851771774 | |
| E-mail:Contact | |
| URL:http://www.ki.se | Organization Type:Education |
Description
Objective:
Preterm and newborn infant may suffer from pain in the same way as adults. They are even more sensitive to pain due to immaturity of endogenous modulation. Thus, they should have the same human right to be alleviated from pain. The overall aim of this project is to assess effects and safety of opioid treatment in very preterm up to full term newborn infants in relation to pharmacokinetics predisposition. Furthermore, a major goal is to develop a PUMA for safe administration of opioid analgesic treatment in newborn infant. Both morphine and fentanyl are off-labelled (EMEA) drugs. Several studies have shown that opioid treatment in newborn reduce pain and stress responses. However, these drugs also have side-effects related to plasma concentrations of the drugs and their metabolites. The new approach in the current project is to obtain a more personalized drug therapy to the newborn infant, and to consider individual differences in pharmacokinetics, as well as gender effects. We will perform a multinational European survey of practices regarding sedation and analgesia in neonatal units. Clinical multicenter trial evaluating safety aspects of morphine and fentanyl will be performed. The responses (evaluated with validated pain scales) will be related to pharmacokinetics predisposition. A
Achievements:
General information:
Project Details
Start date:2008-10-01
End date:2013-09-30
Duration:60 months
Project Reference:223767
Project cost:2881489 EURO
Project Funding:2299164 EURO
Programme Acronym:
FP7-HEALTH
Programme type:Seventh Framework Programme
Subprogramme Area:Adapting off-patent medicines to the specific needs of paediatric populations
Contract type:Small or medium-scale focused research project
URL:
Subject index:Social Aspects, Medicine, Health
Other Indexes:pain,pharmacokinetics,Newborn,preterm,analgesia morpjine
Results for this Project
| Periodic Report Summary - NEOOPIOID (No pain during infancy by adapting off-patent medicines) | 23/07/2012 |
Other participants
| Organization name:THE UNIVERSITY OF EDINBURGH | |
| Administrative contact | Address |
|
Name:Angela |
OLD COLLEGE, SOUTH BRIDGE EDINBURGH UNITED KINGDOM Region:SCOTLAND BORDERS-CENTRAL-FIFE-LOTHIAN-TAYSIDE Lothian |
| Tel:+44-1316509024 | |
| Fax:+44-1316509023 | |
| E-mail:Contact | |
| URL:http://www.ed.ac.uk | Organization Type:Education |
| Organization name:UNIVERSITY OF LEICESTER | |
| Administrative contact | Address |
|
Name:Marie |
University Road LEICESTER UNITED KINGDOM Region:EAST MIDLANDS LEICESTERSHIRE, NORTHAMPTONSHIRE Leicestershire |
| Tel:+44-1162231799 | |
| Fax:+44-1162522028 | |
| E-mail:Contact | |
| URL:http://www.le.ac.uk | Organization Type:Education |
| Organization name:UNIVERSITEIT ANTWERPEN | |
| Administrative contact | Address |
|
Name:Anne |
PRINSSTRAAT 13 ANTWERPEN BELGIQUE-BELGIË Region:VLAAMS GEWEST ANTWERPEN Antwerpen (Arrondissement) |
| Tel:+32-32653028 | |
| Fax:+32-32653011 | |
| E-mail:Contact | |
| URL:http://www.ua.ac.be | Organization Type:Education |
| Organization name:OREBRO UNIVERSITY | |
| Administrative contact | Address |
|
Name:Johan |
FAKULTETSGATAN 1 OEREBRO SVERIGE Region: |
| Tel:+46-19303418 | |
| Fax:+46-19303465 | |
| E-mail:Contact | |
| URL:http://www.oru.se | Organization Type:Education |
| Organization name:UPPSALA UNIVERSITET | |
| Administrative contact | Address |
|
Name:Lena |
St Olofsgatan 10B Box 256 UPPSALA SVERIGE Region:SVERIGE ÖSTRA MELLANSVERIGE Uppsala län |
| Tel:+46-186114877 | |
| Fax:+46-186115583 | |
| E-mail:Contact | |
| URL:http://www.uu.se | Organization Type:Education |
| Organization name:EUROPEAN PAEDIATRIC MEDICINE COMPANY | |
| Administrative contact | Address |
|
Name:Jacques |
Dreve Sainte-Anne 68B BRUXELLES BELGIQUE-BELGIË Region:REG.BRUXELLES-CAP./BRUSSELS HFDST. GEW. |
| Tel:+32-495582000 | |
| Fax:+32-22702618 | |
| E-mail:Contact | |
| URL:http://www.epmc-pharma.com | Organization Type: |
| Organization name:ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS | |
| Administrative contact | Address |
|
Name:Christophe |
3 Avenue Victoria PARIS FRANCE Region:ÎLE DE FRANCE Ile de France Paris |
| Tel:+33-144841770 | |
| Fax:+33-144841788 | |
| E-mail:Contact | |
| URL:http://www.aphp.fr | Organization Type:Education,Other |
| Organization name:LUNDS UNIVERSITET | |
| Administrative contact | Address |
|
Name:Vineta |
Paradisgatan 5c 117 LUND SVERIGE Region:SVERIGE SYDSVERIGE Malmöhus län |
| Tel:+46-46178279 | |
| Fax:+46-46177051 | |
| E-mail:Contact | |
| URL:http://www.lu.se | Organization Type:Education |
| Organization name:ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM | |
| Administrative contact | Address |
|
Name:Ronald |
's Gravendijkwal 230 2040 ROTTERDAM NEDERLAND Region:WEST-NEDERLAND NOORD-HOLLAND Agglomeratie Haarlem |
| Tel:+31-104633119 | |
| Fax:+31-104367894 | |
| E-mail:Contact | |
| URL:http://www.erasmusmc.nl | Organization Type:Other |
| Organization name:FRIEDRICH-ALEXANDER UNIVERSITAET ERLANGEN-NUERNBERG | |
| Administrative contact | Address |
|
Name:Ulrike |
Schlossplatz 4 3520 ERLANGEN DEUTSCHLAND Region:BAYERN MITTELFRANKEN Erlangen, Kreisfreie Stadt |
| Tel:+49-91318534043 | |
| Fax:+49-91318526239 | |
| E-mail:Contact | |
| URL:http://www.uni-erlangen.de | Organization Type:Education |
| Organization name:UNIVERSITE LIBRE DE BRUXELLES | |
| Administrative contact | Address |
|
Name:Angélique |
Avenue Franklin Roosevelt 50 BRUXELLES BELGIQUE-BELGIË Region:REG.BRUXELLES-CAP./BRUSSELS HFDST. GEW. |
| Tel:+32-26503240 | |
| Fax:+32-26502321 | |
| E-mail:Contact | |
| URL:http://www.ulb.ac.be | Organization Type:Education |
| Organization name:HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ | |
| Administrative contact | Address |
|
Name:Merja |
STENBACKINKATU 9 100 HELSINKI SUOMI/FINLAND Region:MANNER-SUOMI UUSIMAA |
| Tel:+358-947173023 | |
| Fax:+358-947175404 | |
| E-mail:Contact | |
| URL:http://www.hus.fi | Organization Type: |
Record control number:89980
