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Beta cell therapy in Diabetes

Start date:2010-01-01

End date:2014-12-31

Project Acronym:BETACELLTHERAPY

Project status:Execution

Coordinator

Organization name:VRIJE UNIVERSITEIT BRUSSEL
Administrative contact Address
Name:Christel HENDRIECKX (Dr) PLEINLAAN 2

BRUSSEL
BELGIQUE-BELGIË

Region:
Tel:+32-24774559
Fax:+32-24774545
E-mail:Contact
URL:http://www.vub.ac.be Organization Type:Education

Description


Objective: Type 1 diabetes is a serious chronic disease with major health risks and heavy burden on patients and society. It is caused by massive immune-mediated loss of insulin-producing beta cells in the pancreas that can so far not be locally corrected. A cellular allotransplant in the liver can install a new beta cell mass but the size is insufficient and the procedure faces limitations of donor shortage, inaccessibility of the implants, risks of associated immunosuppression.

Our consortium of research, clinical and bioindustry teams is focused on overcoming these obstacles and implementing a roadmap for translation to preclinical models and clinical trials. We will pursue three interacting tracks. First, our ability to induce beta cell progenitors and stimulate beta cell proliferation in vivo should lead us to cells and compounds that activate this process in a diabetic pancreas, thus activating endogenous beta cell regeneration. Second, we will produce human beta (progenitor) cells in vitro by derivation from stem cells as well as from reprogrammed autologous cells; their therapeutic potential will be compared to that of primary human beta cells following implantation in rodents using a site that is accessible to modulation and monitoring. Third, we will design an antibody-based therapy for inducing immune tolerance to regenerated beta cells and to a beta cell implant. Efficacy, safety and regulatory criteria will be determined for clinical implementation.

Clinical protocols will be prepared by adjusting associated therapy and by adopting an accessible and controlled implant site. Clinical trials will benefit from state-of-the art biologic markers for comparative analysis of the developed forms of beta cell therapy. This program should provide proof of principle for strategies that make beta cell transplantation and beta cell regeneration realistic for large numbers of type 1 diabetic patients, and probably also for some categories of type 2 diabetes.

Achievements:

General information:

Project Details


Start date:2010-01-01

End date:2014-12-31

Duration:60 months

Project Reference:241883

Project cost:15897619 EURO

Project Funding:11700000 EURO

Programme Acronym: FP7-HEALTH

Programme type:Seventh Framework Programme

Subprogramme Area:Cell therapy for tissue and organs

Contract type:Large-scale integrating project

URL:

Subject index:Medical biotechnology, Medicine, Health
 

Results for this Project

Periodic Report Summary - BETACELLTHERAPY (Beta cell therapy in diabetes)  20/09/2012 

Documents for this Project

Periodic Report - BETACELLTHERAPY (Beta cell therapy in diabetes)  20/09/2012 

Other participants

Organization name:JUVENILE DIABETES RESEARCH FOUNDATION CENTER FOR BETA CELL THERAPY IN DIABETES
Administrative contact Address
Name:Christel HENDRIECKX (Dr) Laarbeeklaan 103

BRUSSEL
BELGIQUE-BELGIË

Region:
Tel:+32-24774559
Fax:+32-24774545
E-mail:Contact
URL:http://www.betacelltherapy.org Organization Type:
 
Organization name:ACADEMISCH ZIEKENHUIS LEIDEN - LEIDS UNIVERSITAIR MEDISCH CENTRUM
Administrative contact Address
Name:Bart O. ROEP (Professor) Albinusdreef 2

LEIDEN
NEDERLAND

Region:WEST-NEDERLAND ZUID-HOLLAND Agglomeratie Leiden en Bollenstreek
Tel:+31-715263869
Fax:+31-715265267
E-mail:Contact
URL:http://www.lumc.nl Organization Type:
 
Organization name:KATHOLIEKE UNIVERSITEIT LEUVEN
Administrative contact Address
Name:Maria VEREEKEN (Ms.) Oude Markt 13

LEUVEN
BELGIQUE-BELGIË

Region:VLAAMS GEWEST VLAAMS BRABANT Leuven
Tel:+32-16326504
Fax:+32-16326515
E-mail:Contact
URL:http://www.kuleuven.be Organization Type:Education
 
Organization name:INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Administrative contact Address
Name:Annick BERTAULT (Ms.) 101 Rue de Tolbiac

PARIS
FRANCE

Region:ÎLE DE FRANCE Ile de France Paris
Tel:+33-140784901
Fax:+33-140784997
E-mail:Contact
URL:http://www.inserm.fr Organization Type:Education
 
Organization name:UNIVERSITE DE LILLE II - DROIT ET SANTE
Administrative contact Address
Name:Marie GOMPEL (Dr) RUE PAUL DUEZ 42

LILLE
FRANCE

Region:NORD - PAS-DE-CALAIS Nord - Pas-de-Calais Nord
Tel:+33-320965215
Fax:+33-320965223
E-mail:Contact
URL:http://www.univ-lille2.fr Organization Type:
 
Organization name:CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Administrative contact Address
Name:Liliane FLABBÉE (Ms.) Rue Michel -Ange 3

PARIS
FRANCE

Region:ÎLE DE FRANCE Ile de France Paris
Tel:+33-142349417
Fax:+33-142349508
E-mail:Contact
URL:http://www.cnrs.fr Organization Type:
 
Organization name:THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Administrative contact Address
Name:Keith CANN (Mr) The Old Schools, Trinity Lane

CAMBRIDGE
UNITED KINGDOM

Region:EAST ANGLIA Cambridgeshire
Tel:+44-1223333543
Fax:+44-1223332988
E-mail:Contact
URL:http://www.cam.ac.uk Organization Type:Education
 
Organization name:FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
Administrative contact Address
Name:Mario VALSECCHI (Mr) Via Olgettina 60

MILANO
ITALIA

Region:LOMBARDIA
Tel:+39-0226432729
Fax:+39-0226432752
E-mail:Contact
URL:http://www.sanraffaele.org Organization Type:Other
 
Organization name:ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Administrative contact Address
Name:Emmanuelle SAVIOZ-DAYER (Ms.) BATIMENT CE 3316 STATION 1

LAUSANNE
SCHWEIZ/SUISSE/SVIZZERA

Region:RÉGION LÉMANIQUE Vaud
Tel:+41-216931633
Fax:+41-213142468
E-mail:Contact
URL:http://www.epfl.ch Organization Type:Education
 
Organization name:THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Administrative contact Address
Name:Herman WALDMANN (Professor) University Offices, Wellington Square

OXFORD
UNITED KINGDOM

Region:SOUTH EAST (UK) BERKSHIRE, BUCKINGHAMSHIRE, OXFORDSHIRE Oxfordshire
Tel:+44-1865275502
Fax:+44-1865275501
E-mail:Contact
URL:http://www.ox.ac.uk Organization Type:
 
Organization name:NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
Administrative contact Address
Name:Wenche LINDSETH (Ms.) Hogskoleringen 1

TRONDHEIM
NORGE

Region:TRØNDELAG Sør-Trøndelag
Tel:+47-73597862
Fax:+47-73591283
E-mail:Contact
URL:http://www.ntnu.no Organization Type:
 
Organization name:BETA-CELL
Administrative contact Address
Name:Sven ANDRÉASSON (Mr) RESEARCHPARK Z.1. 310

ZELLIK
BELGIQUE-BELGIË

Region:VLAAMS GEWEST VLAAMS BRABANT Halle-Vilvoorde
Tel:+32-24774354
Fax:+32-2774350
E-mail:Contact
URL:http://www.beta-cell.com Organization Type:
 
Organization name:REGION HOVEDSTADEN
Administrative contact Address
Name:Horst DONNERSTAG (Mr) KONGENS VAENGE 2

HILLEROD
DANMARK

Region:
Tel:+45-35455981
Fax:+45-35455206
E-mail:Contact
URL:http://www.regionh.dk Organization Type:
 
Organization name:VIACYTE, INC CORPORATION
Administrative contact Address
Name:Anne SANDAN (Ms.) GENERAL ATOMICS COURT 3550

SAN DIEGO CA
UNITED STATES

Region:
Tel:+1-8584553711
Fax:+1-8584553962
E-mail:Contact
URL:http://www.viacyte.com Organization Type:
 
Organization name:SARL ENDOCELLS
Administrative contact Address
Name:Anne-fabienne WEITSCH (Dr) Boulevard Saint Germain 216

PARIS
FRANCE

Region:ÎLE DE FRANCE Ile de France Paris
Tel:+33-610680433
Fax:
E-mail:Contact
URL:http://www.endocells.fr Organization Type:
 
Organization name:THE HEBREW UNIVERSITY OF JERUSALEM.
Administrative contact Address
Name:Eran VARDI (Dr) GIVAT RAM CAMPUS

JERUSALEM
ISRAEL

Region:
Tel:+972-26586676
Fax:+972-26513205
E-mail:Contact
URL:http://www.huji.ac.il Organization Type:Education
 

Record control number:93426



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