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Selective Antibodies Limited Immuno Assay Novel Technology
Start date:2010-09-01
End date:2013-08-31
Project Acronym:SALIANT
Project status:Execution
Coordinator
| Organization name:UNIVERSITY OF NEWCASTLE UPON TYNE | |
| Administrative contact | Address |
|
Name:Aleona |
Kensington Terrace 6 NEWCASTLE UPON TYNE UNITED KINGDOM Region:NORTH NORTHUMBERLAND, TYNE AND WEAR Tyne and Wear |
| Tel:+44-191-2824528 | |
| Fax:+44-191-2824524 | |
| E-mail:Contact | |
| URL:http://www.newcastle.ac.uk | Organization Type:Education |
Description
Objective:
SALIANT aims to develop a hand-held device for real-time analysis of trace levels of explosives, chemicals and drugs. The key innovation is a positive detection lateral-flow test for small molecules that is highly sensitive and simple to use making it ideally suited to deployment by First Responders at crime scenes and terrorist incidents. Lateral flow immunodiagnostics has long offered the promise of fast, high quality testing for substances of low molecular weight. There have however been very real challenges to bringing the full power of such technology to bear in this area.
The problem is simply size. Large analytes can support the simultaneous binding of both capture and detector antibodies, allowing typical excess-reagent sandwich immunoassays to be formatted in which increasing analyte concentration provides an increase of observable signal over a very low zero background. Small molecules are simply not large enough to support such simultaneous binding.
Alternative systems in effect measure how much analyte is not present. This causes major problems in terms of precision, sensitivity and read-out where, classically, increasing concentration of analyte reduces the signal produced, making point-of-need devices often difficult to read. What is required is a robust system in which there is no observable signal in the absence of analyte, and even low level samples give an obvious observable signal over this zero background.
SALIANT offers a system based on a small bindable moiety that is first conjugated close to the binding site of a primary antibody against the analyte such that when analyte binds the antibody, the moiety can still be bound by a labelled secondary antibody. A large reagent-analogue of the analyte is also introduced, binding analyte-unbound primary antibody, and thereby blocking binding of the secondary antibody to the moiety. Thus the more analyte present, the more binding of secondary antibody occurs and the more signal is produced.
Achievements:
General information:
Project Details
Start date:2010-09-01
End date:2013-08-31
Duration:36 months
Project Reference:242377
Project cost:4472718 EURO
Project Funding:3362598 EURO
Programme Acronym:
FP7-SECURITY
Programme type:Seventh Framework Programme
Subprogramme Area:Advanced forensic toolbox
Contract type:Collaborative project (generic)
URL:
Subject index:Security
Results for this Project
| Periodic Report Summary - SALIANT (Selective Antibodies Limited Immuno Assay Novel Technology) | 18/01/2013 |
Documents for this Project
| Periodic Report - SALIANT (Selective Antibodies Limited Immuno Assay Novel Technology) | 18/01/2013 |
Other participants
| Organization name:STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK | |
| Administrative contact | Address |
|
Name:Ruben |
Costerweg 50 9101 WAGENINGEN NEDERLAND Region:NOORD-NEDERLAND FRIESLAND Noord-Friesland |
| Tel:+31-317482985 | |
| Fax:+31-317483011 | |
| E-mail:Contact | |
| URL: | Organization Type: |
| Organization name:SELECTIVE ANTIBODIES LIMITED | |
| Administrative contact | Address |
|
Name:Colin |
CELS at Newcastle William Leech Building Framlington Place NEWCASTLE UPON TYNE UNITED KINGDOM Region:NORTH NORTHUMBERLAND, TYNE AND WEAR Tyne and Wear |
| Tel:+44-1912235604 | |
| Fax:+44-1912235601 | |
| E-mail:Contact | |
| URL:http://selectiveantibodies.com/www/ | Organization Type: |
| Organization name:ZILINSKA UNIVERZITA V ZILINE | |
| Administrative contact | Address |
|
Name:Ladislav |
UNIVERZITNA 8215/1 ZILINA SLOVENSKA REPUBLIKA Region:SLOVENSKA REPUBLIKA STREDNE SLOVENSKO Zilinsky kraj |
| Tel:+421-415136601 | |
| Fax:+421-415136620 | |
| E-mail:Contact | |
| URL:http://www.uniza.sk | Organization Type: |
| Organization name:NETHERLANDS FORENSIC INSTITUTE | |
| Administrative contact | Address |
|
Name:Marcel |
Laan van Ypenburg 6 24044 THE HAGUE NEDERLAND Region:WEST-NEDERLAND ZUID-HOLLAND Oost-Zuid-Holland |
| Tel:+31-708886666 | |
| Fax: | |
| E-mail:Contact | |
| URL:http://www.forensicinstitute.nl | Organization Type: |
| Organization name:DEPARTMENT OF JUSTICE, EQUALITY & LAW REFORM | |
| Administrative contact | Address |
|
Name:Catriona |
St. Stephen's Green 94 DUBLIN ÉIRE/IRELAND Region:ÉIRE/IRELAND Dublin |
| Tel:+353-16662910 | |
| Fax:+353-16662929 | |
| E-mail:Contact | |
| URL: | Organization Type: |
| Organization name:OY REAGENA LTD | |
| Administrative contact | Address |
|
Name:Markku Tuomo Olavi |
Takojantie 18 TOIVALA SUOMI/FINLAND Region:MANNER-SUOMI ITÄ-SUOMI Pohjois-Savo |
| Tel:+358-173688500 | |
| Fax:+358-173688530 | |
| E-mail:Contact | |
| URL:http://www.reagena.fi | Organization Type: |
| Organization name:APPLIKON ANALYTICAL | |
| Administrative contact | Address |
|
Name:Timeor |
De Brauwweg 13 149 SCHIEDAM NEDERLAND Region:WEST-NEDERLAND ZUID-HOLLAND Groot-Rijnmond |
| Tel:+31-102983500 | |
| Fax:+31-102983554 | |
| E-mail:Contact | |
| URL:http://www.applikon-analyzers.com | Organization Type: |
| Organization name:CENTRE OF EXCELLENCE FOR LIFE SCIENCES LTD | |
| Administrative contact | Address |
|
Name:Anthea |
QUORUM 16 NEWCASTLE UPON TYNE UNITED KINGDOM Region:NORTH NORTHUMBERLAND, TYNE AND WEAR Tyne and Wear |
| Tel:+44-1912155025 | |
| Fax:+44-1912155125 | |
| E-mail:Contact | |
| URL:http://www.celsgroup.com/home.html | Organization Type: |
| Organization name:KITE INNOVATION (EUROPE) LIMITED | |
| Administrative contact | Address |
|
Name:Derek |
The Media Centre, Northumberland Street 7 HUDDERSFIELD UNITED KINGDOM Region:YORKSHIRE AND HUMBERSIDE WEST YORKSHIRE |
| Tel:+44-1484437466 | |
| Fax:+44-1484483100 | |
| E-mail:Contact | |
| URL:http://www.kiteinnovation.com | Organization Type: |
| Organization name:INDICIA BIOTECHNOLOGY | |
| Administrative contact | Address |
|
Name:Stephane |
avenue de la Californie 33 OULLINS FRANCE Region:CENTRE-EST RHÔNE-ALPES Rhône |
| Tel:+33-680758946 | |
| Fax:+33-472391601 | |
| E-mail:Contact | |
| URL:http://www.indicia.fr | Organization Type: |
Record control number:95761
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