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Embryomics : reconstructing in space and time the cell lineage tree
Start date:2005-11-01
End date:2009-04-30
Project Acronym:EMBRYOMICS
Project status:Completed
Coordinator
| Organization name:CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE | |
| Contact person | Address |
|
Name:Nadine |
UPR 2197 - DÉVELOPPEMENT, ÉVOLUTION ET PLASTICITÉ DU SYSTÈME NERVEUX CNRS CREA 3 rue Michel-Ange PARIS FRANCE Region:ÎLE DE FRANCE Ile de France Paris |
| Tel:+1-44323955 | |
| Fax:+1-44323988 | |
| E-mail:Contact | |
| URL:http://www.cns.fr | Organization Type: |
Description
Objective:
Embryomics is devoted to the morphodynamical "reconstruction" of the cell lineage tree underlying the processes of animal embryogenesis. We will design a set of strategies, methods and algorithms to "sequence" the cell lineage tree as a branching process a nnotated in space and time. We view this highly interdisciplinary project as the foundation of a new scientific field that we call Embryomics with a reference to Genomics. In the same sense as Genomics, Embryomics is both a scientific field and a technolog y to gather data with a lot of potential applications. But the Embryomics data is much more 'complex' than a mere DNA sequence as it does not appear as a linear static information in one dimension but as a branching dynamical process displayed in space and time. To deal with this information, we undertake a highly novel and most promising approach based on the strategies of the mammalian visual system. Our goal is to fully reconstruct the dynamics of cell divisions and movements from time-lapse series of hi gh-resolution optical sections obtained by multiphoton laser scanning microscopy throughout embryonic development of live animals. Embryomics will allow the automated tracking of events such as cell division and cell death in live embryos and give us acces s to parameters such as the rate of cell proliferation in time and space. This kind of data is highly relevant to investigate stem cell populations, early steps of cancerogenesis and drug effects in vivo. The post-genomic era needs such a systematic approa ch at the level of the cellular organization to achieve an integrated understanding of biological processes. In addition, through the investigation of four different organisms with key phylogenetic positions, we aim at promoting the use of non-mammalian an imal models. A comparative Embryomics strategy is the best way to evaluate the relevance of animal models, whatever their evolutionary distance to human, for further medical applications.
Achievements:
General information:
Project Details
Start date:2005-11-01
End date:2009-04-30
Duration:42 months
Project Reference:12916
Project cost:2336433 EURO
Project Funding:1449850 EURO
Programme Acronym:
FP6-NEST
Programme type:Sixth Framework Programme
Subprogramme Area:Adventure activities
Contract type:Specific Targeted Research Project
URL:
Subject index:Scientific Research
Other Indexes:theory,Comparative,embryology Computational,vision Singularity
Other participants
| Organization name:SLOVENSKA TECHNICKA UNIVERZITA V BRATISLAVE | |
| Contact person | Address |
|
Name:Karol |
DEPARTMENT OF MATHEMATICS AND DESCRIPTIVE GEOMETRY/ FACULTY OF CIVIL ENGINEERING Vazovova 5 BRATISLAVA SLOVENSKA REPUBLIKA Region:SLOVENSKA REPUBLIKA BRATISLAVSKY Bratislavsky kraj |
| Tel:+41-2259274418 | |
| Fax:+421-252967027 | |
| E-mail:Contact | |
| URL:http://www.stuba.sk | Organization Type:Education |
| Organization name:INSTITUT PASTEUR | |
| Contact person | Address |
|
Name:Jean-François |
MOLECULAR BIOLOGY DEVELOPMENT UNIT 28-25 rue Dr Roux PARIS FRANCE Region:ÎLE DE FRANCE Ile de France Paris |
| Tel:+33-145688524 | |
| Fax:+33-145688521 | |
| E-mail:Contact | |
| URL: | Organization Type:Research |
| Organization name:ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA' | |
| Contact person | Address |
|
Name:Alessandro |
DEPARTMENT OF ELECTRONICS, INFORMATION AND SYSTEMS (DEIS) via Zamboni BOLOGNA ITALIA Region:EMILIA-ROMAGNA Bologna |
| Tel:+39-0512093091 | |
| Fax:+39-0512093073 | |
| E-mail:Contact | |
| URL: | Organization Type:Education |
Record control number:78531