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Capture and enrichment of emerging pathogens for multiple and ultra-sensitive diagnostic
Start date:2006-11-01
End date:2010-04-30
Project Acronym:USDEP
Project status:Completed
Coordinator
| Organization name:ROBERT KOCH-INSTITUT | |
| Administrative contact | Address |
|
Name:Heinz |
ROBERT KOCH-INSTITUT Nordufer 20 BERLIN DEUTSCHLAND Region:BERLIN |
| Tel:+49-30-187542258 | |
| Fax:+49-30-187542605 | |
| E-mail:Contact | |
| URL:http://www.rki.de | Organization Type:Research |
Description
Objective:
In the 1970's WHO proclaimed that eradication of smallpox should be attempted. This goal has been achieved 1979. There is now consensus that list of newly emerging or re-emerging pathogens is continuously growing. During the last decades pathogens such as Marburg, Ebola, Hepatitis-C and Hantavirus, HIV and more recently, SARS coronavirus have emerged. Today the risk of a new influenza pandemic again highlights the global threat of infectious diseases. In addition, the possibility of bioterrorist attacks using highly pathogenic viruses and bacteria can not be ignored. Furthermore, the requirements for sensitivity and specifity of diagnostics have increased. A major obstacle for the detection of pathogens in clinical or environmental samples are false negative results, e.g. for HCV "occult infections". This is mainly due to the lack of a rapid and reliable pathogen concentration methodology, and the inability of most of the currently used technologies to eliminate or neutralize interfering "natural inhibitors" present in samples. The aim of this research program is to exploit the "non-self" recognition and binding properties of human apolipoprotein H (ApoH). ApoH binds and captures pathogens enabling their concentration from different biological samples. Magnetic beads coated with ApoH recombinant protein can be efficiently used as a pretreatment step to greatly improve the detection threshold and thereby increasing the sensitivity for diagnosis of emerging pathogens, regardless of the molecular techniques used for their diagnosis. The project will focus on viruses and bacteria from clinical and environmental samples including those that could be used in bioterrorism. In addition to the incorporation of ApoH into regular molecular techniques for pathogen detection, mini-array chips will be developed for multiple and ultra-sensitive pathogen diagnosis.'
Achievements:
General information:
Project Details
Start date:2006-11-01
End date:2010-04-30
Duration:42 months
Project Reference:37560
Project cost:3417323 EURO
Project Funding:2004952 EURO
Programme Acronym:
FP6-LIFESCIHEALTH
Programme type:Sixth Framework Programme
Subprogramme Area:Development of new diagnostics
Contract type:Specific Targeted Research Project
URL:
Subject index:Medicine, Health, Biotechnology, Life Sciences
Other participants
| Organization name:IMMUNOCLIN LIMITED | |
| Administrative contact | Address |
|
Name:Dorothy |
IMMUNOCLIN LIMITED Rowlandson House 289 to 293 Ballards lane LONDON UNITED KINGDOM Region:SOUTH EAST (UK) GREATER LONDON |
| Tel:+44-1494565545 | |
| Fax:+44-1494565545 | |
| E-mail:Contact | |
| URL:http://www.immunoclin.com | Organization Type:Industry |
| Organization name:APOH-TECHNOLOGIES | |
| Administrative contact | Address |
|
Name:Elias |
APOH TECHNOLOGIES 94 Allée des Fauvettes LA GRANDE MOTTE FRANCE Region:MÉDITERRANÉE LANGUEDOC-ROUSSILLON Hérault |
| Tel:+33-467412284 | |
| Fax:+33-467041495 | |
| E-mail:Contact | |
| URL: | Organization Type:Industry |
| Organization name:INSTITUT DE RECHERCHES POUR LE DÉVELOPPEMENT | |
| Administrative contact | Address |
|
Name:Francisco |
UR MALADIES VIRALES EMERGENTES/LABORATOIRE D'IMMUNOLOGIE RÉTROVIRALE ET MOLÉCULAIRE' 44, Bd de Dunkerke, CS 90009 MARSEILLE FRANCE Region:MÉDITERRANÉE PROVENCE-ALPES-CÔTE D'AZUR Bouches-du-Rhône |
| Tel:+33-681416506 | |
| Fax:+33-467528380 | |
| E-mail: | |
| URL:http://www.ird.fr | Organization Type: |
| Organization name:GENEXPRESS GESELLSCHAFT FÜR PROTEINDESIGN GMBH | |
| Administrative contact | Address |
|
Name:Roland |
GENEXPRESS GESELLSCHAFT FÜR PROTEINDESIGN Eresburgstr. 22-23 BERLIN DEUTSCHLAND Region:BERLIN |
| Tel:+49-3078709828 | |
| Fax:+49-3078709827 | |
| E-mail:Contact | |
| URL:http://www.genexpress.de | Organization Type: |
| Organization name:SARL SKULD-TECH | |
| Administrative contact | Address |
|
Name:David |
SKULD-TECH/CONTROLIFE Rue du Curat, 134 MONTPELLIER FRANCE Region:MÉDITERRANÉE LANGUEDOC-ROUSSILLON Hérault |
| Tel:+33-467419748 | |
| Fax:+33-467526396 | |
| E-mail:Contact | |
| URL:http://www.skuldtech.com | Organization Type:Industry |
| Organization name:FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. | |
| Administrative contact | Address |
|
Name:Gundula |
FRAUNHOFER-INSTITUT FÜR SILIZIUMTECHNOLOGIE (ISIT) Hansastrasse 27 C MÜNCHEN DEUTSCHLAND Region:BAYERN OBERBAYERN München, Kreisfreie Stadt |
| Tel:+49-4821/174319 | |
| Fax:+49-4821/174350 | |
| E-mail:Contact | |
| URL:http://www.fraunhofer.de | Organization Type:Other |
| Organization name:PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE | |
| Administrative contact | Address |
|
Name:Marcelo |
CENTRO DE INVESTIGACIONES MEDICAS/FACULTAD DE MEDICINA/PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE/LABORATORIO DE VIROLOGIA MOLECULAR 114-D Avenida del Libertador Bernardo O'Higgins 340 SANTIAGO CHILE Region: |
| Tel:+56-2-3543410 | |
| Fax:+56-26387457 | |
| E-mail:Contact | |
| URL:http://www.puc.cl/ | Organization Type: |
| Organization name:EBIOCHIP SYSTEMS GMBH | |
| Administrative contact | Address |
|
Name:Ralf |
DEPT. R&D Fraunhoferstr.1 ITZEHOE DEUTSCHLAND Region:SCHLESWIG-HOLSTEIN Schleswig-Holstein Kiel, Kreisfreie Stadt |
| Tel:+49-04821-174313 | |
| Fax:+49-04821-174250 | |
| E-mail:Contact | |
| URL:http://www.ebiochip.com | Organization Type:Industry |
Record control number:85005
