| :: About Projects |
Light-based functional in vivo monitoring of diseases related enzymes
Start date:2009-11-01
End date:2013-04-30
Project Acronym:LIVIMODE
Project status:Completed
Coordinator
| Organization name:INSTITUT JOZEF STEFAN | |
| Administrative contact | Address |
|
Name:Jadran |
Jamova 39 3000 LJUBLJANA SLOVENIJA Region:SLOVENIJA Slovenija Savinjska |
| Tel:+386-14773513 | |
| Fax:+386-14773906 | |
| E-mail:Contact | |
| URL:http://www.ijs.si | Organization Type:Research |
Description
Objective:
LIVIMODE aims to develop specific tools for non invasive in vivo imaging of disease related molecular events. Such tools are of high relevance for disease detection, staging, developing animal models of human disease, and evaluating novel therapies. We propose to use optical imaging, which is optimally suited for this task as it provides excellent sensitivity and allows visualizing molecular events via a fluorescent signal. While optical imaging technology has rapidly evolved over the last years, the availability of SMART (activatable) imaging agents that change their fluorescence properties upon disease related events, remains a critical gap. The LIVIMODE project proposes to combine expertises in medicinal chemistry, pharmacology and imaging in a conceptually new approach in designing SMART agents. In particular, we will (i) translate established strategies in medicinal/pharmaceutical chemistry to design highly selective SMART probes and (ii) optimize the cell/tissue specificity of probes integrating concepts from polymer and protein based targeted drug delivery. We will generate a toolset of highly selective targeted SMART probes for at least 10 disease-relevant proteases. The selection of target proteases is based on their relevance in disease processes that cannot yet be monitored with non invasive technology. These include (i) the development of tumor microenvironment as a critical factor in oncogenesis, (ii) tumor hypoxia and angiogenesis, and (iii) inflammatory and degenerative processes in osteoarthritis. LIVIMODE has established animal models for these conditions and will use in vivo optical imaging to evaluate the novel SMART probes as tools for monitoring disease progression and drug efficacy. This will enhance our knowledge of disease mechanisms and our ability to rapidly characterize drug candidates for in vivo efficacy (proof-of-efficacy). Selected SMART probes will be optimized to assess their potential as clinical diagnostics.
Achievements:
General information:
Project Details
Start date:2009-11-01
End date:2013-04-30
Duration:42 months
Project Reference:241919
Project cost:6867435 EURO
Project Funding:4850785 EURO
Programme Acronym:
FP7-HEALTH
Programme type:Seventh Framework Programme
Subprogramme Area:Activatable or smart in vivo imaging agents reporting on physico-chemical or molecular changes relevant to the diagnosis and/or monitoring of diseases
Contract type:Small or medium-scale focused research project
URL:
Subject index:Medical biotechnology, Medicine, Health
Results for this Project
| Periodic Report Summary - LIVIMODE (Light-based functional in vivo monitoring of diseases related enzymes) | 18/01/2013 |
Other participants
| Organization name:UNIVERSITAET ZUERICH | |
| Administrative contact | Address |
|
Name:Markus |
Raemistrasse 71 ZURICH SCHWEIZ/SUISSE/SVIZZERA Region:ZÜRICH Zürich |
| Tel:+41-446337604 | |
| Fax:+41-446331187 | |
| E-mail:Contact | |
| URL:http://www.uzh.ch | Organization Type:Education |
| Organization name:EUROPEAN MOLECULAR BIOLOGY LABORATORY | |
| Administrative contact | Address |
|
Name:Phil |
Meyerhofstrasse 1 HEIDELBERG DEUTSCHLAND Region:BADEN-WÜRTTEMBERG KARLSRUHE Heidelberg, Stadtkreis |
| Tel:+49-62213878239 | |
| Fax:+49-62213878275 | |
| E-mail:Contact | |
| URL:http://www.embl.org | Organization Type:Research |
| Organization name:FREIE UNIVERSITAET BERLIN | |
| Administrative contact | Address |
|
Name:Bianca |
Kaiserswertherstrasse 16-18 BERLIN DEUTSCHLAND Region:BERLIN |
| Tel:+49-3083852523 | |
| Fax:+49-3083853448 | |
| E-mail:Contact | |
| URL:http://www.fu-berlin.de | Organization Type:Education |
| Organization name:IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE | |
| Administrative contact | Address |
|
Name:Michael |
Exhibition Road, South Kensington Campus LONDON UNITED KINGDOM Region:SOUTH EAST (UK) GREATER LONDON |
| Tel:+44-02075943866 | |
| Fax:+44-20-75943282 | |
| E-mail:Contact | |
| URL:http://www.imperial.ac.uk | Organization Type:Education |
| Organization name:UNIVERSITAT AUTONOMA DE BARCELONA | |
| Administrative contact | Address |
|
Name:Francesc Xavier |
Campus UAB -BELLATERRA- s/n CERDANYOLA DEL VALLES ESPAÑA Region:ESTE CATALUÑA Barcelona |
| Tel:+34-935811315 | |
| Fax:+34-935812011 | |
| E-mail:Contact | |
| URL:http://www.uab.es | Organization Type: |
| Organization name:SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT | |
| Administrative contact | Address |
|
Name:Paul |
Pierre Brossolette 1 CHILLY MAZARIN FRANCE Region:ÎLE DE FRANCE Ile de France Essonne |
| Tel:+33-534632564 | |
| Fax:+33-534632286 | |
| E-mail:Contact | |
| URL:http://sanofi-aventis.com | Organization Type: |
| Organization name:COMMISSARIAT A L' ENERGIE ATOMIQUE | |
| Administrative contact | Address |
|
Name:Vincent |
RUE LEBLANC 25 PARIS 15 FRANCE Region:ÎLE DE FRANCE Ile de France Paris |
| Tel:+33-169082603 | |
| Fax:+33-169089071 | |
| E-mail:Contact | |
| URL:http://www.cea.fr | Organization Type:Research |
| Organization name:FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPE FELIPE | |
| Administrative contact | Address |
|
Name:Mª José |
Avenida Autopista Del Saler 16-3 VALENCIA ESPAÑA Region:ESTE COMUNIDAD VALENCIANA Valencia |
| Tel:+963-289680 | |
| Fax: | |
| E-mail:Contact | |
| URL:http://www.ochoa.fib.es | Organization Type: |
| Organization name:SANOFIS AVENTIS DEUTSCHLAND GMBH | |
| Administrative contact | Address |
|
Name:Anissa |
Industriepark Hoechst - Building G879 FRANKFURT/MAIN DEUTSCHLAND Region: |
| Tel:+49-6930531750 | |
| Fax:+49-6930580667 | |
| E-mail:Contact | |
| URL:http://www.sanofi-aventis.de | Organization Type: |
| Organization name:THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD | |
| Administrative contact | Address |
|
Name:Linda |
University Offices, Wellington Square OXFORD UNITED KINGDOM Region:SOUTH EAST (UK) BERKSHIRE, BUCKINGHAMSHIRE, OXFORDSHIRE Oxfordshire |
| Tel:+44-1865289800 | |
| Fax:+44-1865289801 | |
| E-mail:Contact | |
| URL:http://www.ox.ac.uk | Organization Type:Education |
Record control number:93295
