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Identification of epigenetic markers underlying increased risk of T2D in South Asians
Start date:2011-12-01
End date:2014-11-30
Project Acronym:EPI-MIGRANT
Project status:Execution
Coordinator
| Organization name:IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE | |
| Administrative contact | Address |
|
Name:Tatjana |
Exhibition Road, South Kensington Campus LONDON UNITED KINGDOM Region:SOUTH EAST (UK) GREATER LONDON |
| Tel:+44-2075943866 | |
| Fax: | |
| E-mail:Contact | |
| URL:http://www.imperial.ac.uk | Organization Type:Education |
Description
Objective:
This project focuses on identification of epigenetic risk factors underlying the increased rates of type-2 diabetes (T2D) amongst South Asians in their home countries, migrants to Europe and other parts of the world. Known environmental and genetic factors explain only a small part of the increased risk of T2D among South Asians, who constitute the highest numbers of people with T2D worldwide. We hypothesise that epigenetic modification contributes to the increased T2D risk amongst South Asians. We will carry out an epigenome-wide scan of DNA methylation in whole blood, among T2D cases and controls from non-migrant (living in India or Pakistan) and migrant (living in the UK) South Asians. Further testing of top-ranking markers will be carried out in South Asian T2D cases and controls from UK, India, Mauritius, Pakistan, Singapore and Sri Lanka. We will use results to investigate the mechanisms underlying the epigenetic modifications identified, to develop a predictive panel of lifestyle, environmental, genetic and epigenetic markers increasing susceptibility to incident T2D in South Asians, and to quantify the contribution of these risk factors to T2D amongst South Asians in diverse regional settings. This research will improve understanding of epigenetic mechanisms underlying T2D, and may enable development of novel biomarkers and therapeutic strategies to reduce the burden of T2D amongst South Asians worldwide.
Achievements:
General information:
Project Details
Start date:2011-12-01
End date:2014-11-30
Duration:36 months
Project Reference:279143
Project cost:3903100 EURO
Project Funding:2999052 EURO
Programme Acronym:
FP7-HEALTH
Programme type:Seventh Framework Programme
Subprogramme Area:Genetic and environmental factors in obesity and/or diabetes in specific populations
Contract type:Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries(SICA)
URL:http://www.epimigrant.eu
Subject index:Life Sciences
Other participants
| Organization name:THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD | |
| Administrative contact | Address |
|
Name:Stephen |
Wellington Square OXFORD UNITED KINGDOM Region:SOUTH EAST (UK) BERKSHIRE, BUCKINGHAMSHIRE, OXFORDSHIRE Oxfordshire |
| Tel:+44-1865289811 | |
| Fax:+44-1865289801 | |
| E-mail:Contact | |
| URL:http://www.ox.ac.uk | Organization Type: |
| Organization name:OULUN YLIOPISTO | |
| Administrative contact | Address |
|
Name:Arto |
Pentti Kaiteran Katu 1 PL 8000 OULU SUOMI/FINLAND Region:MANNER-SUOMI POHJOIS-SUOMI Pohjois-Pohjanmaa |
| Tel:+358-85534133 | |
| Fax:+358-85534170 | |
| E-mail:Contact | |
| URL:http://www.oulu.fi | Organization Type: |
| Organization name:NATIONAL UNIVERSITY OF SINGAPORE | |
| Administrative contact | Address |
|
Name:Shyong |
KENT RIDGE CRESCENT 10 000 SINGAPORE SINGAPORE Region: |
| Tel:+65-65166666 | |
| Fax: | |
| E-mail:Contact | |
| URL:http://www.nus.edu.sg | Organization Type:Education |
| Organization name:THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE | |
| Administrative contact | Address |
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Name:Danish |
The Old Schools, Trinity Lane CAMBRIDGE UNITED KINGDOM Region:EAST ANGLIA Cambridgeshire |
| Tel:+44-01223741450 | |
| Fax: | |
| E-mail:Contact | |
| URL:http://www.cam.ac.uk | Organization Type:Education |
| Organization name:HELSINGIN YLIOPISTO | |
| Administrative contact | Address |
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Name:Tiina |
YLIOPISTONKATU 4 HELSINGIN YLIOPISTO SUOMI/FINLAND Region: |
| Tel:+358-0919125129 | |
| Fax: | |
| E-mail:Contact | |
| URL:http://www.helsinki.fi/university/ | Organization Type:Education |
| Organization name:UNIVERSITA DEGLI STUDI DI MILANO | |
| Administrative contact | Address |
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Name:Pier Alberto |
Via Festa Del Perdono 7 MILANO ITALIA Region:LOMBARDIA |
| Tel:+39-025450812 | |
| Fax: | |
| E-mail:Contact | |
| URL:http://www.unimi.it | Organization Type:Education |
| Organization name:UNIVERSITY OF MAURITIUS | |
| Administrative contact | Address |
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Name:Chaya |
Reduit REDUIT MAURITIUS Region: |
| Tel:+230-4037615 | |
| Fax: | |
| E-mail:Contact | |
| URL:http://www.uom.ac.mu/ | Organization Type: |
| Organization name:CELLCENTRIC LIMITED | |
| Administrative contact | Address |
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Name:Tim |
CHESTERFORD RESEARCH PARK, LITTLE CHESTERFORD CAMBRIDGE UNITED KINGDOM Region:EAST ANGLIA Cambridgeshire |
| Tel:+44-1799531130 | |
| Fax: | |
| E-mail:Contact | |
| URL:http://www.cellcentric.com | Organization Type: |
| Organization name:DEVKI DEVI FOUNDATION SOCIETY | |
| Administrative contact | Address |
|
Name:Sujeet |
PRESS ENCLAVE ROAD SAKET 2 NEW DELHI INDIA Region: |
| Tel:9910609000 | |
| Fax: | |
| E-mail:Contact | |
| URL:http://www.maxhealthcare.in | Organization Type: |
| Organization name:BAKER IDI HEART AND DIABETES INSTITUTE HOLDINGS LIMITED | |
| Administrative contact | Address |
|
Name:Heather |
COMMERCIAL ROAD 75 VICTORIA MELBOURNE AUSTRALIA Region: |
| Tel:+61-385321771 | |
| Fax:+61-385321100 | |
| E-mail:Contact | |
| URL:http://www.bakeridi.edu.au | Organization Type: |
| Organization name:UNIVERSITY OF KELANIYA | |
| Administrative contact | Address |
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Name:Ar |
DALUGAMA KELANIYA SRI LANKA Region: |
| Tel:+94-112955280 | |
| Fax: | |
| E-mail:Contact | |
| URL:http://www.med.kln.ac.lk | Organization Type: |
| Organization name:NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE | |
| Administrative contact | Address |
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Name:Terumasa |
Toyama 1-21-1 TOKYO JAPAN Region: |
| Tel:+81-352736825 | |
| Fax: | |
| E-mail:Contact | |
| URL: | Organization Type: |
Record control number:101230
