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Emerging variants of hepatitis b virus: new tools for epidemiological survey, diagnosis of infection, and monitoring of drug resistance (HEPBVAR)
Start date:2001-09-01
End date:2005-02-28
Project Acronym:HEPBVAR
Project status:Completed
Coordinator
| Organization name:INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE | |
| Administrative contact | Address |
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Name:Christian |
U 271 -VIRUS DES HEPATITES, RETROVIRUS HUMAINS ET PATHOLOGIES ASSOCIEES Cours Albert Thomas 151 ADR 5 - Rhône-Alpes, Auve 69424 LYON FRANCE Region:CENTRE-EST RHÔNE-ALPES Rhône |
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| URL: | Organization Type:Research |
Description
Objective:
Hepatitis B virus (HBV) chronic infection still poses a major health problem for Europe. The emergence of HBV variants will compound the problem if they are allowed to spread, leading to vaccine escape and chemotherapeutic failure. To prevent this, our collaborative study will: develop high throughput procedures for detecting these variants in patients from different parts of Europe; evaluate their immune escape and drug resistance phenotypes through the use of conventional and new cell culture and animal models; and establish quantification assays to monitor the dynamic of HBV variants during therapy. Our findings should lead to re-design of diagnostic assays, and of vaccine and therapeutic formulations, and to guidelines to biologists and clinicians for better prevention and treatment strategies. They should result in the reduction of HBV transmission and of severe liver disease in chronically infected patients.
Achievements:
General information:
Project Details
Start date:2001-09-01
End date:2005-02-28
Duration:42 months
Project Reference:QLK2-CT-2001-00977
Project cost:2200574 EURO
Project Funding:1565030 EURO
Programme Acronym:
LIFE QUALITY
Programme type:Fifth Framework Programme
Subprogramme Area:Key action Control of Infectious Diseases
Contract type:Cost-sharing contracts
URL:
Subject index:Safety, Social Aspects, Scientific Research, Medicine, Health, Life Sciences
Other participants
| Organization name:UNIVERSITY OF GDANSK | |
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Name:Andrzej |
INTERCOLLEGIATE FACULTY OF BIOTECHNOLOGY DEPARTMENT OF BIOTECHNOLOGY Kladki 24 80 822 GDANSK POLSKA Region:POMORSKIE Gdansk-Gdynia-Sopot |
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| URL: | Organization Type:Education |
| Organization name:HEALTH PROTECTION AGENCY | |
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Name:Paul |
SEXUALLY TRANSMITTED AND BLOOD-BORNE VIRUS LABORATORY 61 Colindale Avenue NW9 5HT LONDON UNITED KINGDOM Region:SOUTH EAST (UK) GREATER LONDON |
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| Organization name:AZIENDA OSPEDALIERA PISANA | |
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Name:Ferruccio |
U.O. GASTROENTEROLOGIA ED EPATOLOGIA Via Paradisa 2 - Cisanello 56127 PISA ITALIA Region:CENTRO (I) TOSCANA Pisa |
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| URL: | Organization Type:Other |
| Organization name:BIOMERIEUX SA | |
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Name:Benoit |
LABORATOIRE DE DIAGNOSTIC MOLECULAIRE Rue du Dr. Levy 33 69200 VENISSIEUX FRANCE Region:CENTRE-EST RHÔNE-ALPES Rhône |
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| URL: | Organization Type:Other |
Record control number:58588