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Pulmonary Hypertension: Functional Genomics and Therapy of Lung Vascular Remodelling
Start date:2006-01-01
End date:2009-12-31
Project Acronym:PULMOTENSION
Project status:Completed
Coordinator
| Organization name:JUSTUS-LIEBIG-UNIVERSITY GIESSEN | |
| Administrative contact | Address |
|
Name:Werner |
UNIVERSITY GIESSEN LUNG CENTRE Ludwigstrasse 23 GIESSEN DEUTSCHLAND Region:HESSEN GIEßEN Gießen, Landkreis |
| Tel:+49-64199-42350 | |
| Fax:+49-64199- 42359 | |
| E-mail:Contact | |
| URL:http://www.uglc.de | Organization Type:Education |
Description
Objective:
Pulmonary hypertension (PH) describes devastating diseases, comprising idiopathic and secondary forms, which cause breathlessness and premature death, representing a major burden on healthcare systems. Extensive lung vascular remodelling with loss of vessel patency is the underlying pathomechanism. PULMOTENSION integrates the top EU Centres in PH and lung vascular biology in a multidisciplinary approach, aiming to combat and finally cure PH. The expertise of all members extends from the initial discovery of gene mutations causative of PH to having established new therapeutic regimen of PH. We will uncover underlying molecular pathways, identify distinct targets for anti-remodelling therapy, foster drug development based on these targets, and test these new treatment options in preclinical and clinical trials. The presented project includes a) genetics of PH, b) functional genomics and proteomics to unravel the molecular pathways underlying vascular remodelling, c) characterisation of the cross-talk between different cells and signalling pathways involved, d) preclinical trials in PH models including transgenics, e) a European PH Tissue Bank and Registry, f) conversion of target discovery into drug design and exploitation, g) development of non-invasive clinical tools for monitoring lung vascular remodelling in patients, h) a Clinical Trial Network to conduct phase I/II(III) studies focussing on anti- and reversal of remodelling in PH patients, and i) promotion of a world-leading infrastructure for scientific and technical competence in the field of PH, including training and mobility programs, technology transfer in alliance with industry and exploitation facilities. Gender issues will be particularly addressed, as many PH forms have a female preponderance. Hence, this ambitious translational research programme will span from molecules to patients to the benefit of molecular understanding and new treatments of PH, a prototype disease of vascular remo
Achievements:
General information:
Project Details
Start date:2006-01-01
End date:2009-12-31
Duration:48 months
Project Reference:18725
Project cost:13962116 EURO
Project Funding:11399999 EURO
Programme Acronym:
FP6-LIFESCIHEALTH
Programme type:Sixth Framework Programme
Subprogramme Area:Functional genomics of vascular remodelling
Contract type:Integrated Project
URL:
Subject index:Medicine, Health, Biotechnology
Results for this Project
| Final Report Summary - PULMOTENSION (Pulmonary Hypertension: Functional Genomics and Therapy of Lung Vascular Remodelling) | 14/04/2011 |
Documents for this Project
| Final Report - PULMOTENSION (Pulmonary Hypertension: Functional Genomics and Therapy of Lung Vascular Remodelling) | 14/04/2011 |
Other participants
| Organization name:ALPHALYSE A/S | |
| Administrative contact | Address |
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Name:Thomas |
ALPHALYSE A/S Unsbjergvej 2A ODENSE DANMARK Region:DANMARK Danmark Fyns amt |
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| Fax:+45-63106509 | |
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| URL:http://www.alphalyse.com | Organization Type:Industry |
| Organization name:DR. RIETHMÜLLER M/R/S GMBH | |
| Administrative contact | Address |
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Name:Hilde |
DR. RIETHMÜLLER M/R/S GMBH Mittelweg 27 FRANKFURT/MAIN DEUTSCHLAND Region: |
| Tel:+49-691302560 | |
| Fax:+49-6913025629 | |
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| URL:http://www.drmrs.com | Organization Type:Other |
| Organization name:DUALSYSTEMS BIOTECH AG | |
| Administrative contact | Address |
|
Name:Michael |
DUALSYSTEMS BIOTECH AG Winterthurerstrasse 190 ZURICH DEUTSCHLAND Region: |
| Tel:+41-16355470 | |
| Fax:+41-6356869 | |
| E-mail:Contact | |
| URL:http://www.dualsystems.com | Organization Type:Industry |
| Organization name:GENOLYZE LTD | |
| Administrative contact | Address |
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Name:Marko |
GENOLYZE LTD Lemminkäisenkatu 14-18 A 140 TURKU SUOMI/FINLAND Region:MANNER-SUOMI ETELÄ-SUOMI Varsinais-Suomi |
| Tel:+358-106338180 | |
| Fax:+358-106338189 | |
| E-mail:Contact | |
| URL:http://www.genolyze.com | Organization Type:Industry |
| Organization name:ASSISTANCE PUBLIQUE HOPITAUX DE PARIS | |
| Administrative contact | Address |
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Name:Gérald |
UPRES EA2705 Avenue Victoria 3 PARIS FRANCE Region:ÎLE DE FRANCE Ile de France Paris |
| Tel:+33-145374776 | |
| Fax:+33-146303824 | |
| E-mail:Contact | |
| URL: | Organization Type:Research |
| Organization name:HOSPITAL CLINÍC I PROVINCIAL DE BARCELONA | |
| Administrative contact | Address |
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Name:Joan Albert |
DEPARTMENT OF PNEUMOLOGY c/ Villarroel, 170 BARCELONA ESPAÑA Region:ESTE CATALUÑA Barcelona |
| Tel:+34-932275540 | |
| Fax:+34-932275455 | |
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| URL:http://www.hospitalclinic.org | Organization Type:Other |
| Organization name:IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE, LONDON | |
| Administrative contact | Address |
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Name:Martin |
EXPERIMENTAL MEDICINE, IMPERIAL COLLEGE LONDON Exhibition Road, South Kensington LONDON UNITED KINGDOM Region:SOUTH EAST (UK) GREATER LONDON |
| Tel:+44-02083832049 | |
| Fax:+44-402083832066 | |
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| URL:http://www.imperial.ac.uk | Organization Type:Education |
| Organization name:CHARITÉ - UNIVERSITÄTSMEDIZIN BERLIN | |
| Administrative contact | Address |
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Name:Wolfgang M. |
INSTITUTE OF PHYSIOLOGY, CHARITÉ UNIVERSITY MEDICINE BERLIN, CAMPUS BENJAMIN FRANKLIN Schumannstarsse 20-21 BERLIN DEUTSCHLAND Region:BERLIN |
| Tel:+49-3084451648 | |
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| URL:http://www.fu-berlin.de/physio | Organization Type:Education |
| Organization name:LEA MEDIZINTECHNIK GMBH | |
| Administrative contact | Address |
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Name:Alfons |
LEA MEDIZINTECHNIK GMBH Winchesterstr. 2 GIESSEN DEUTSCHLAND Region:HESSEN GIEßEN Gießen, Landkreis |
| Tel:+49-641969880 | |
| Fax:+49-6419698812 | |
| E-mail:Contact | |
| URL:http://www.lea.de | Organization Type:Industry |
| Organization name:LUXCEL BIOSCIENCES LTD. | |
| Administrative contact | Address |
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Name:Dmitri Boris |
LUXCEL BIOSCIENCES 22A Ballymany Park NEWBRIDGE, CO. KILDARE ÉIRE/IRELAND Region: |
| Tel:+353-21-4904257 | |
| Fax:+353-21-4904257 | |
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| URL:http://www.luxcel.com | Organization Type:Industry |
| Organization name:MEDICAL SCHOOL OF HANNOVER | |
| Administrative contact | Address |
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Name:Tobias |
DEPARTMENT OF PNEUMOLOGY Carl-Neuberg-Str. 1 6870 HANNOVER DEUTSCHLAND Region:NIEDERSACHSEN HANNOVER Hannover, Kreisfreie Stadt |
| Tel:+49-511-5323530 | |
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| URL:http://www.mh-hannover.de | Organization Type:Research |
| Organization name:MEDICAL UNIVERSITY GRAZ | |
| Administrative contact | Address |
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Name:Horst |
MEDICAL UNIVERSITY CLINIC, DIVISION OF PULMONOLOGY Auenbruggerplatz 2 GRAZ ÖSTERREICH Region:SÜDÖSTERREICH STEIERMARK Graz |
| Tel:+43-3163852183 | |
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| URL:http://www.meduni-graz.at | Organization Type:Education |
| Organization name:MEDICAL UNIVERSITY OF VIENNA | |
| Administrative contact | Address |
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Name:Irene |
DEPARTMENT OF INTERNAL MEDICINE II, DIVISION OF CARDIOLOGY Spitalgasse 23 VIENNA ÖSTERREICH Region:OSTÖSTERREICH WIEN |
| Tel:+43-1-404004614 | |
| Fax:+43-1-4081148 | |
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| URL:http://www.meduniwien.ac.at | Organization Type:Education |
| Organization name:BIOSPRING GMBH | |
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Name:Hüseyin |
BIOSPRING GMBH Alt Fechenheim FRANKFURT AM MAIN DEUTSCHLAND Region:HESSEN DARMSTADT Frankfurt am Main, Kreisfreie Stadt |
| Tel:+49-6940807222 | |
| Fax:+49-6940894489 | |
| E-mail:Contact | |
| URL:http://www.biospring.de | Organization Type:Industry |
| Organization name:GREATER GLASGOW HEALTH BOARD | |
| Administrative contact | Address |
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Name:Andrew |
SCOTTISH PULMONARY VASCULAR UNIT / WESTERN INFIRMARY 300 Balgrayhill Road GLASGOW UNITED KINGDOM Region:SCOTLAND DUMFRIES & GALLOWAY, STRATHCLYDE Strathclyde |
| Tel:+44-141-2116327 | |
| Fax:+44-141-2116334 | |
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| URL:http://www.spvu.co.uk | Organization Type:Other |
| Organization name:TRANSMIT GESELLSCHAFT FÜR TECHNOLOGIETRANSFER MBH | |
| Administrative contact | Address |
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Name:Christian |
TRANSMIT GMBH Kerkrader Strasse 3 GIESSEN DEUTSCHLAND Region:HESSEN GIEßEN Gießen, Landkreis |
| Tel:+49-641943640 | |
| Fax:+49-6419436499 | |
| E-mail:Contact | |
| URL:http://www.transmit.de | Organization Type:Other |
| Organization name:UNIVERSITÉ LIBRE DE BRUXELLES | |
| Administrative contact | Address |
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Name:Robert |
DEPARTMENT OF PATHOPHYSIOLOGY, FACULTY OF MEDICINE, ULB Avenue Franklin Roosevelt 50 BRUSSELS BELGIQUE-BELGIË Region:REG.BRUXELLES-CAP./BRUSSELS HFDST. GEW. |
| Tel:+32-2-5553322 | |
| Fax:+32-2-5554124 | |
| E-mail:Contact | |
| URL: | Organization Type:Education |
| Organization name:UNIVERSITY COLLEGE LONDON | |
| Administrative contact | Address |
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Name:James Mitchell |
CENTRE FOR CLINICAL PHARMACOLOGY, THE RAYNE INSTITUTE Gower Street LONDON UNITED KINGDOM Region:SOUTH EAST (UK) GREATER LONDON |
| Tel:+44-2076796535 | |
| Fax: | |
| E-mail:Contact | |
| URL:http://www.ucl.ac.uk | Organization Type:Education |
| Organization name:ALMA MATER STUDIORUM - UNIVERSITÀ DI BOLOGNA | |
| Administrative contact | Address |
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Name:Nazzareno |
UNIVERSITY OF BOLOGNA PULMONARY HYPERTENSION CENTER Via Zamboni 33 BOLOGNA ITALIA Region:EMILIA-ROMAGNA Bologna |
| Tel:+39-51-349858 | |
| Fax:+39-51-344859 | |
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| Organization name:THE CHANCELLORS, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE | |
| Administrative contact | Address |
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Name:Nicholas |
DEPARTMENT OF MEDICINE, ADDENBROOKE'S HOSPITAL The Old Schools, Trinity Lane CAMBRIDGE UNITED KINGDOM Region:EAST ANGLIA Cambridgeshire |
| Tel:+44-1223336744 | |
| Fax:+44-1223762007 | |
| E-mail:Contact | |
| URL:http://www.cam.ac.uk | Organization Type:Education |
| Organization name:UNIVERSITÄTSKLINIKUM DUISBURG-ESSEN | |
| Administrative contact | Address |
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Name:Joachim |
INSTITUT FÜR PHYSIOLOGIE, UNIVERSITÄTSKLINIKUM ESSEN, MEDIZINISCHE FAKULTÄT Hufelandstr. 55 ESSEN DEUTSCHLAND Region:NORDRHEIN-WESTFALEN DÜSSELDORF Essen, Kreisfreie Stadt |
| Tel:+49-201-7234601 | |
| Fax:+49-201-7234648 | |
| E-mail:Contact | |
| URL:http://www.uniklinikum-essen.de | Organization Type:Education |
| Organization name:UNIVERSITY OF GLASGOW | |
| Administrative contact | Address |
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Name:Margaret |
FACULTY OF BIOMEDICINE AND LIFE SCIENCE, WEST MEDICAL BUILDING University Avenue GLASGOW UNITED KINGDOM Region:SCOTLAND DUMFRIES & GALLOWAY, STRATHCLYDE Strathclyde |
| Tel:+44-141-3304768 | |
| Fax:+44-141-3302923 | |
| E-mail:Contact | |
| URL:http://www.gla.ac.uk | Organization Type:Education |
| Organization name:KING´S COLLEGE LONDON | |
| Administrative contact | Address |
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Name:Richard Charles |
DEPT OF MEDICAL AND MOLECULAR GENETICS Strand LONDON UNITED KINGDOM Region:SOUTH EAST (UK) GREATER LONDON |
| Tel:+44-2071883173 | |
| Fax:+44-2071882585 | |
| E-mail:Contact | |
| URL:http://www.kcl.ac.uk | Organization Type: |
| Organization name:UNIVERSITY OF SEVILLA | |
| Administrative contact | Address |
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Name:Jose |
LABORATORIO DE INVESTIGACIONES BIOMEDICAS, HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO c/ San Fernando 4 SEVILLA ESPAÑA Region:SUR ANDALUCIA Sevilla |
| Tel:+34-955012648 | |
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| E-mail:Contact | |
| URL:http://www.us.es | Organization Type:Education |
| Organization name:UNIVERSITY OF ZURICH | |
| Administrative contact | Address |
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Name:Max |
INSTITUTE OF VETERINARY PHYSIOLOGY, UNIVERSITY OF ZURICH Rämistrasse 71 ZURICH SCHWEIZ/SUISSE/SVIZZERA Region:ZÜRICH Zürich |
| Tel:+41-16358803 | |
| Fax:+41-16358932 | |
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| URL:http://www.unizh.ch | Organization Type:Education |
| Organization name:INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE | |
| Administrative contact | Address |
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Name:Serge |
INSERM U651: FONCTIONS CELLULAIRE ET MOLECULAIRES DE L´APPAREIL RESPIRATOIRE AT DES VAISSEAUX 101 Rue de Tolbiac PARIS FRANCE Region:ÎLE DE FRANCE Ile de France Paris |
| Tel:+33-148984603 | |
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| URL:http://www.inserm.fr | Organization Type:Research |
| Organization name:THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD | |
| Administrative contact | Address |
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Name:Christopher W. |
WELLCOME TRUST CENTRE FOR HUMAN GENETICS University Offices, Wellington Square OXFORD UNITED KINGDOM Region:SOUTH EAST (UK) BERKSHIRE, BUCKINGHAMSHIRE, OXFORDSHIRE Oxfordshire |
| Tel:+44-1865887669 | |
| Fax:+44-1865887501 | |
| E-mail:Contact | |
| URL:http://www.ox.ac.uk | Organization Type:Education |
| Organization name:UNIVERSITÄTSKLINIKUM HEIDELBERG | |
| Administrative contact | Address |
|
Name:Bart |
INSTITUTE OF HUMAN GENETICS DEPARTMENT OF CARDIOLOGY AND PNEUMOLOGY Im Neuenheimer Feld 672 HEIDELBERG DEUTSCHLAND Region:BADEN-WÜRTTEMBERG KARLSRUHE Heidelberg, Stadtkreis |
| Tel:+49-62265639568 | |
| Fax:+49-6221565332 | |
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| URL:http://www.med.uni-heidelberg.de | Organization Type: |
| Organization name:UNIVERSITY OF IOANNINA, MEDICAL SCHOOL | |
| Administrative contact | Address |
|
Name:Savvas |
MEDICAL SCHOOL/UNIVERSITY OF IOANNINA/LABORATORY OF BIOLOGICAL CHEMISTRY BIOMEDICAL RESEARCH INSTITUTE/FOUNDATION FOR RESEARCH AND TECHNOLOGY - HELLAS (BRI-FORTH) University Campus 1186 IOANNINA HELLAS Region:KENTRIKI ELLADA IPEIROS Ioannina |
| Tel:+30-2651097808 | |
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| URL:http://www.uoi.gr/ | Organization Type: |
| Organization name:NYCOMED GMBH | |
| Administrative contact | Address |
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Name:Christian |
BIOCHEMISTRY RDP/BC Byk Gulden Str. 2 KONSTANZ DEUTSCHLAND Region:BADEN-WÜRTTEMBERG FREIBURG Konstanz |
| Tel:+49-7531844682 | |
| Fax:+49-75318494682 | |
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| URL:http://www.nycomed.com | Organization Type:Industry |
Record control number:78433
