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:: About Projects

Curing autoimmune disease. A translational approcah to autoimmune diseases in the post-genomic era using inflammatory arthritis and myositis as prototypes and learning examples.

Start date:2006-03-01

End date:2011-02-28

Project Acronym:AUTOCURE

Project status:Completed

Coordinator

Organization name:KAROLINSKA INSTITUTET
Administrative contact	Address
Name:Lars KLARESKOG (Professor)	DEPARTMENT OF MEDICINE, RHEUMATOLOGY UNIT Nobels vag 5 STOCKHOLM SVERIGE Region:SVERIGE STOCKHOLM
Tel:+46-851774529
Fax:+46-851773080
E-mail:Contact
URL:http://www.ki.se	Organization Type:

Description

Objective: Objective: To transform knowledge obtained from molecular research particularly within genomics, into a cure in an increasing number of patients suffering from inflammatory rheumatic diseases. Rheumatoid arthritis (RA) is used as a prototype since this disease offers unique opportunities to define and evaluate new therapies.

State of the art and beyond: Development of the first generation of targeted therapies (anti-TNF and anti-IL-1) in chronic inflammatory disease used RA as the prototype disease after work from European investigators included in the current IP. This work demonstrated (i) that targeted therapies can be efficient and (ii) that cure is still not achieved, but is within reach through a strong international consortium covering translational research and molecular technology.

Work plan: -Potential key molecular mechanisms determining the course of RA and myositis are defined from genetic studies in humans, from relevant animal models and from basic cell and molecular biology.
- Predictors of disease development and therapeutic responses, enabling future individualised therapies, are developed with the help of our unique large patient cohorts and, biobanks..
- Development and evaluation of new therapies is performed using combinations of novel molecular tools and precise definition of disease phenotypes.

Impact of the project: We aim to produce (i) an increased understanding of the causes of RA and myositis enabling better prevention; (ii) new potential targets for therapy in arthritis and myositis, which can be further tested in other rheumatic inflammatory diseases; (iii) a prototype system for translational research in Europe, enabling collaborative development of targeted therapies in many inflammatory diseases and enabling European SMEs to rapidly develop ideas and patents into targeted therapies in inflammatory diseases.

Achievements:

General information:

Project Details

Start date:2006-03-01

End date:2011-02-28

Duration:60 months

Project Reference:18661

Project cost:13365020 EURO

Project Funding:11000000 EURO

Programme Acronym: FP6-LIFESCIHEALTH

Programme type:Sixth Framework Programme

Subprogramme Area:Post genomic approaches for inflammatory rheumatic disease, leading to the development of improved therapy

Contract type:Integrated Project

URL:

Subject index:Biotechnology, Medicine, Health, Life Sciences
 

Other participants

Organization name:BIOVITRUM AB
Administrative contact	Address
Name:Peter OLOFSSON (Dr)	BIOVITRUM AB, DISCOVERY GOTEBORG Berzelius vag 8 STOCKHOLM SVERIGE Region:SVERIGE STOCKHOLM
Tel:+46-317491127
Fax:+46-317491101
E-mail:Contact
URL:http://www.biovitrum.com	Organization Type:Industry
Organization name:INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Administrative contact	Address
Name:Christian JORGENSEN (Professor)	INSERM U 475 101 rue de Tolbiac PARIS FRANCE Region:
Tel:+33-467337798
Fax:+33-467337798
E-mail:Contact
URL:http://www.inserm.fr	Organization Type:Research
Organization name:LEIDEN UNIVERSITY MEDICAL CENTER
Administrative contact	Address
Name:Tom HUIZINGA (Professor)	DEPARTMENT OF RHEUMATOLOGY, LUMC Albinusdreef 2 9600 LEIDEN NEDERLAND Region:
Tel:+31-715263598
Fax:+31-715266752
E-mail:Contact
URL:http://www.lumc.nl	Organization Type:
Organization name:CHARITE UNIVERSITATSMEDIZIN, BERLIN
Administrative contact	Address
Name:Burmester GERD (Professor)	DEPARTMENT OF RHEUMATOLOGY AND CLINICAL IMMUNOLOGY Schumannstr. 20/21 BERLIN DEUTSCHLAND Region:BERLIN
Tel:+49-30450513061
Fax:+49-30450513917
E-mail:Contact
URL:http://www.charite.de	Organization Type:
Organization name:MEDICAL UNIVERSITY OF VIENNA
Administrative contact	Address
Name:Josef SMOLEN (Professor)	RHEUMATOLOGY, INTERNAL MEDICINE III, MEDICAL UNIVERSITY OF VIENNA Spitalgasse 23 VIENNA ÖSTERREICH Region:
Tel:+43-1404004301
Fax:+43-1404004331
E-mail:Contact
URL:http://www.meduniwien.ac.at	Organization Type:
Organization name:ST VINCENT'S UNIVERSITY HOSPITAL
Administrative contact	Address
Name:Bresnihan BARRY (Professor)	DEPARTMENT OF RHEUMATOLOGY, ST VINCENT'S UNIVERSITY HOSPITAL AND UNIVERSITY COLLEGE DUBLIN Elm Park DUBLIN 4 ÉIRE/IRELAND Region:
Tel:+353-12774737
Fax:+353-2839420
E-mail:Contact
URL:http://www.st-vincents.ie	Organization Type:Other
Organization name:ACADEMIC MEDICAL CENTER / UNIVERSITY OF AMSTERDAM
Administrative contact	Address
Name:Paul Peter TAK (Professor)	AMC MEDICL RESEARCH, CLINICAL IMMUNOLOGY AND RHEUMATOLOGY, F4-218 Meibergdreef 9 22700 AMSTERDAM NEDERLAND Region:
Tel:+31-205662171
Fax:+31-206919658
E-mail:
URL:http://www.reuma-onderzoek.nl	Organization Type:
Organization name:IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Administrative contact	Address
Name:Andrew COPE (Dr)	KENNEDY INSTITUTE OF RHEUMATOLOGY DIVISION, FACULTY OF MEDICINE, IMPERIAL COLLEGE Exhibition Road LONDON UNITED KINGDOM Region:
Tel:+44-2083834412
Fax:+44-2083834499
E-mail:Contact
URL:http://www.imperial.ac.uk	Organization Type:
Organization name:STICHTING KATHOLIEKE UNIVERSITEIT, MORE PARTICULARLY RADBOUD UNIVERSITY NIJMEGEN MEDICAL CENTRE
Administrative contact	Address
Name:Wim VAN DEN BERG (Professor)	RHEUMATOLOGY RESEARCH AND ADVANCED THERAPEUTICS Geert Grooteplein Zuid 10 9101 NIJMEGEN NEDERLAND Region:
Tel:+31-243616540
Fax:+31-243540403
E-mail:
URL:http://www.umcn.nl	Organization Type:
Organization name:LUND UNIVERSITY
Administrative contact	Address
Name:Tore SAXNE (Professor)	DEPARTMENT OF CLINICAL SCIENCES, LUND, SECTION FOR RHEUMATOLOGY DEPARTMENT OF EXPERIMENTAL MEDICAL SCIENCES, SECTION FOR INFLAMMATION RESEARCH Paradisgatan 5C LUND SVERIGE Region:
Tel:+46-46171627
Fax:+46-46128468
E-mail:Contact
URL:http://www.reum.lu.se	Organization Type:
Organization name:UNIVERISTY OF MANCHESTER
Administrative contact	Address
Name:Jane WORTHINGTON (Professor)	ARC EPIDEMIOLOGY RESEARCH, FACULTY OF MEDICAL & HUMAN SCIENCES Oxford Rd MANCHESTER UNITED KINGDOM Region:
Tel:+44-16127556051
Fax:+44-1612755043
E-mail:
URL:	Organization Type:
Organization name:GENMAB A.S
Administrative contact	Address
Name:Jan VAN DE WINKEL (Professor)	GENMAB BV Toldbodgade 33 9068 COPENHAGEN K DANMARK Region:
Tel:+31-302123123
Fax:+31-302123111
E-mail:Contact
URL:http://www.genmab.com	Organization Type:
Organization name:THE UNIVERSITY OF BIRMINGHAM
Administrative contact	Address
Name:Chris BUCKLEY (Professor)	SCHOOL OF MEDICINE, DIVISION OF IMMUNITY AND INFECTION, MRC CENTRE FOR IMMUNE REGULATION Edgbaston BIRMINGHAM UNITED KINGDOM Region:
Tel:+44-1214146777
Fax:+44-1214145475
E-mail:Contact
URL:http://www.bham.ac.uk	Organization Type:
Organization name:UNIVERSITE D'EVRY VAL D'ESSONNE
Administrative contact	Address
Name:Francois CORNELIS (Dr)	GENHOTEL-EA 3886, LABORATOIRE DE RECHERCHE EUROPEEN POUR LA POLYARTHRITE RHEUMATOIDE rue Francois Mitterrand EVRY FRANCE Region:
Tel:+33-160874570
Fax:+33-160874571
E-mail:Contact
URL:http://www.univ-evry.fr	Organization Type:
Organization name:EUROPEAN LEAGUE AGAINST RHEUMATISM; STANDING COMMITTEE ON INVESTIGATIVE RHEUMATOLOGY, GNOMICS STUDY GROUP. CO DEPT OF RHEUMATOLOGY, CHARITE BERLIN
Administrative contact	Address
Name:Gerd Rudiger BURMESTER (Professor)	DEPT OF RHEUMATOLOGY, CHARITE, UNIVERSITY HOSPITAL, HUMBOLDT UNIVERSITY, BERLIN Seestrsse 240 KILCHBERG SCHWEIZ/SUISSE/SVIZZERA Region:
Tel:+49-30450513061
Fax:+49-30450513917
E-mail:Contact
URL:http://www.eular.org	Organization Type:Other
Organization name:VU UNIVERSITY MEDICAL CENTER
Administrative contact	Address
Name:Cor VERWEIJ (Professor)	DEPT OF MOLECULAR CELL BIOLOGY & IMMUNOLOGY, C270 De Boelelaan 1117 7057 AMSTERDAM NEDERLAND Region:
Tel:+31-205988151
Fax:+31-205988081
E-mail:Contact
URL:http://www.vumc.nl	Organization Type:
Organization name:BIOMEDICAL DIAGNOSTICS SA
Administrative contact	Address
Name:Karine MIGNON-GODEFROY (Dr)	R&D DEPARTMENT 4 boulevard de Beaubourg - Actipole 25 CROISSY BEAUBOURG FRANCE Region:
Tel:+33-164621012
Fax:+33-164629551
E-mail:Contact
URL:http://www.bmd-net.com	Organization Type:Industry
Organization name:ARTHROGEN B.V.
Administrative contact	Address
Name:Margriet VERVOORDELONK (Dr)	ARTHROGEN B.V. Meibergdreef 45 22700 AMSTERDAM NEDERLAND Region:
Tel:+31-020-5662648
Fax:+31-020-5662648
E-mail:Contact
URL:	Organization Type:Industry
Organization name:INSTITUTE OF RHEUMATOLOGY
Administrative contact	Address
Name:Jiri VENCOVSKY (Professor)	INSTITUTE OF RHEUMATOLOGY Na Slupi 4 PRAGUE2 CESKA REPUBLIKA Region:
Tel:+420-224914469
Fax:+420-224914451
E-mail:Contact
URL:http://www.revma.cz	Organization Type:Other
Organization name:REDOXIS AB
Administrative contact	Address
Name:Peter OLOFSSON (Dr)	REDOXIS AB Arvid Wallgrens Backe 20 GOTEBORG SVERIGE Region:
Tel:+46-709164608
Fax:
E-mail:Contact
URL:http://www.redoxis.com	Organization Type:Industry
Organization name:FOUNDATION FOR RESEARCH AND TECHNOLOGY - HELLAS, INSTITUTE OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY
Administrative contact	Address
Name:Dimitrios BOUMPAS (Professor)	IMBB - LABORATORY OF RHEUMATOLOGY, N. Plastira at Vassilika Vouton 1385 HERAKLION HELLAS Region:
Tel:+30-281039463530281039462
Fax:+30-2810392024
E-mail:Contact, sidiropp@med.uoc.gr
URL:http://www.imbb.forth.gr	Organization Type:
Organization name:UNIVERSITY OF ZURICH
Administrative contact	Address
Name:Renate GAY (Professor)	CENTER OF EXPERIMENTAL RHEUMATOLOGY AND WHO COLLABORATING CENTER Raemistrasse 71 ZURICH SCHWEIZ/SUISSE/SVIZZERA Region:
Tel:+41-442555718
Fax:+41-442554170
E-mail:Contact
URL:http://www.rheuma.unispital.ch	Organization Type:
Organization name:PROIMMUNE LIMITED
Administrative contact	Address
Name:Nikolai SCHWARE (Dr)	PROIMMUNE LIMITED MAGDALEN CENTRE, OXFORD SCIENCE PARK OXFORD UNITED KINGDOM Region:SOUTH EAST (UK) BERKSHIRE, BUCKINGHAMSHIRE, OXFORDSHIRE Oxfordshire
Tel:+44-8700427279
Fax:+44-8707120588
E-mail:
URL:http://www.proimmune.com	Organization Type:Industry
Organization name:INSTITUTE OF RHEUMATOLOGY
Administrative contact	Address
Name:Wlodzimierz MASLINSKI (Professor)	DEPT OF PATHOPHYSIOLOGY AND IMMUNOLOGY Spartanska 1 WARSAW POLSKA Region:
Tel:+48-228442540
Fax:+48-228442540
E-mail:Contact
URL:	Organization Type:Other
Organization name:UNIVERSITY OF CRETE
Administrative contact	Address
Name:Dimitrios BOUMPAS (Professor)	LABORATORY OF RHEUMATOLOGY, Leof. Knossou 1352 HERAKLION HELLAS Region:
Tel:+30-2810392024
Fax:+30-2810392062
E-mail:Contact, sidiropp@med.uoc.gr
URL:	Organization Type:
Organization name:OLIGENE GMBH
Administrative contact	Address
Name:Joachim GRUEN (PhD)	OLIGENE GMBH Schumannsstrasse 20/21 BERLIN DEUTSCHLAND Region:
Tel:+49-03028460570
Fax:+49-30450578952
E-mail:
URL:http://www.oligene.com	Organization Type:Industry
Organization name:UME? UNIVERSITY
Administrative contact	Address
Name:Solbritt RANTAPAA-DAHLQVIST (Professor)	DEPARTMENT OF CLINICAL MEDICINE AND PUBLIC HEALTH, RHEUMATOLOGY MEDICAL BIOBANK OF NORTHERN SWEDEN, UNIVERSITY HOSPITAL Universitetsomraadet UMEA SVERIGE Region:
Tel:+46-907851729
Fax:+46-90131567
E-mail:Contact
URL:http://www.umu.se	Organization Type:

Record control number:84793

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