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Development of a high throughput genomics-based test for assessing genotoxic and carcinogenic properties of chemical compounds in vitro
Start date:2006-11-01
End date:2012-04-30
Project Acronym:CARCINOGENOMICS
Project status:Completed
Coordinator
| Organization name:MAASTRICHT UNIVERSITY | |
| Administrative contact | Address |
|
Name:Jos |
TOXICOGENOMICS Minderbroedersberg 4-6 616 MAASTRICHT NEDERLAND Region:ZUID-NEDERLAND LIMBURG (NL) Zuid-Limburg |
| Tel:+31-43-3881096 | |
| Fax:+31-43-3884146 | |
| E-mail:Contact | |
| URL:http://www.maastrichtuniversity.nl | Organization Type: |
Description
Objective:
The major aim of CARCINOGENOMICS is to develop in vitro methods for assessing the carcinogenic potential of compounds, as an alternative to current rodent bioassays for genotoxicity and carcinogenicity. The major goal is to develop a battery of mechanism-based in vitro tests accounting for various modes of carcinogenic action. These tests will be designed to cover major target organs for carcinogenic action e.g. the liver, the lung, and the kidney. The novel assays will be based on the application of "omics" technologies (i.e. genome-wide transcriptomics as well as metabonomics) to robust in vitro systems (rat/human), thereby also exploring stem cell technology, to generate "omic" responses from a well-defined set of model compounds causing genotoxicity and carcinogenicity. Phenotypic markers for genotoxic and carcinogenic events will be assessed for the purpose of anchoring gene expression modulations, metabolic profiles and mechanism pathways.
Through extensive biostatistics, literature mining, and analysis of molecular-expression datasets, differential genetic pathways will be identified capable of predicting mechanisms of chemical carcinogenesis in vivo. Furthermore, generated transcriptomic and metabonomic data will be integrated into a holistic understanding of systems biology, and applied to build an iterative in silico model of chemical carcinogenesis. Subsequently, predictive gene expression profiles, typically consisting of some 150-250 genes, will be loaded onto high throughput dedicated DNA-chips, thus accelerating the analysis of transcriptomic responses by a factor of 100. It is expected that the outcome of this project will generate a platform enabling the investigation of large numbers of compounds for their genotoxic and carcinogenic potential, as envisaged under the REACH initiative. This will contribute to speeding the identification of potential harmful substances to man, while lowering costs and reducing animal tests.
Achievements:
General information:
Project Details
Start date:2006-11-01
End date:2012-04-30
Duration:66 months
Project Reference:37712
Project cost:12619013 EURO
Project Funding:10440000 EURO
Programme Acronym:
FP6-LIFESCIHEALTH
Programme type:Sixth Framework Programme
Subprogramme Area:Predictive in vitro testing strategies for human exposure to chemicals
Contract type:Integrated Project
URL:http://www.carcinogenomics.eu/
Subject index:Life Sciences, Medicine, Health, Biotechnology
Other participants
| Organization name:MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. | |
| Administrative contact | Address |
|
Name:Ralf |
MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS, DEPARTMENT OF VERTEBRATE GENOMICS Hofgartenstr. 8 MÜNCHEN DEUTSCHLAND Region:BAYERN OBERBAYERN München, Kreisfreie Stadt |
| Tel:+49-3084131265 | |
| Fax:+49-3084131380 | |
| E-mail:Contact | |
| URL:http://www.molgen.mpg.de | Organization Type: |
| Organization name:FUNDACION HOSPITAL UNIVERSITARIO LA FE | |
| Administrative contact | Address |
|
Name:José V. |
EXPERIMENTAL HEPATOLOGY UNIT / RESEARCH CENTER. UNIVERSITY HOSPITAL "LA FE" Avda. Campanar 21 VALENCIA ESPAÑA Region:ESTE COMUNIDAD VALENCIANA Valencia |
| Tel:+34-961973048 | |
| Fax:+34-961973018 | |
| E-mail:Contact | |
| URL:http://www.fundacionlafe.org | Organization Type: |
| Organization name:VRIJE UNIVERSITEIT BRUSSEL | |
| Administrative contact | Address |
|
Name:Vera Maria |
DEPARTMENT OF TOXICOLOGY DERMATO-COSMETOLOGY AND PHARMACOGNOSY / FACULTY OF MEDICINE AND PHARMACY / VRIJE UNIVERSITEIT BRUSSEL / FAFY Pleinlaan 2 BRUSSEL BELGIQUE-BELGIË Region: |
| Tel:+32-24774516 | |
| Fax:+32-24774582 | |
| E-mail:Contact | |
| URL:http://www.vub.ac.be | Organization Type: |
| Organization name:EUROPEAN COMMISSION - DG JRC-IHCP-ECVAM "DG JRC" | |
| Administrative contact | Address |
|
Name:Thomas |
INSTITUTE FOR HEALTH AND CONSUMER PROTECTION/EUROPEAN CENTRE FOR VALIDATION OF ALTERNATIVE METHODS Rue de la loi 200 BRUSSELS BELGIQUE-BELGIË Region:REG.BRUXELLES-CAP./BRUSSELS HFDST. GEW. |
| Tel:+39-0332785939 | |
| Fax:+39-0332786297 | |
| E-mail:Contact | |
| URL:http://www.jrc.cec.eu.int | Organization Type:Other |
| Organization name:EUROPEAN MOLECULAR BIOLOGY LABORATORY | |
| Administrative contact | Address |
|
Name:Assunta |
EUROPEAN BIOINFORMATICS INSTITUTE (EBI), MICROARRAY INFORMATICS TEAM Meyerhofstrasse 1 HEIDELBERG DEUTSCHLAND Region:BADEN-WÜRTTEMBERG KARLSRUHE Heidelberg, Stadtkreis |
| Tel:+44-1223494691 | |
| Fax:+44-1223494478 | |
| E-mail:Contact | |
| URL:http://www.embl.org | Organization Type: |
| Organization name:BIOPREDIC INTERNATIONAL SARL | |
| Administrative contact | Address |
|
Name:Nathalie |
BIOPREDIC INTERNATIONAL 8-18 RUE JEAN PECKER RENNES FRANCE Region:OUEST BRETAGNE Ille-et-Vilaine |
| Tel:+33-299143613 | |
| Fax:+33-299544472 | |
| E-mail:Contact | |
| URL:http://www.biopredic.com | Organization Type:Other |
| Organization name:GENEDATA AG | |
| Administrative contact | Address |
|
Name:Jochen |
PROFESSIONAL SERVICES Maulbeerstrasse 46 BASEL SCHWEIZ/SUISSE/SVIZZERA Region:NORDWESTSCHWEIZ Basel-Stadt |
| Tel:+41-61-6976994 | |
| Fax:+41-61-6977244 | |
| E-mail:Contact | |
| URL:http://www.genedata.com | Organization Type:Industry |
| Organization name:CELLARTIS AB | |
| Administrative contact | Address |
|
Name:Petter |
CELLARTIS AB Arvid Wallgrens Backe 20 GOTHENBURG SVERIGE Region: |
| Tel:+46-317580940 | |
| Fax:+46-317580910 | |
| E-mail:petter.bjöContact | |
| URL:http://www.cellartis.com | Organization Type:Industry |
| Organization name:LEIDEN UNIVERSITY MEDICAL CENTER | |
| Administrative contact | Address |
|
Name:Leon |
DEPARTMENT OF TOXICOGENETICS Albinusdreef 2 9600 LEIDEN NEDERLAND Region:NOORD-NEDERLAND GRONINGEN Overig Groningen |
| Tel:+31-71-5269603 | |
| Fax:+31-71-5268284 | |
| E-mail:Contact | |
| URL:http://www.lumc.nl | Organization Type: |
| Organization name:NATIONAL UNIVERSITY OF IRELAND, DUBLIN. UNIVERSITY COLLEGE DUBLIN | |
| Administrative contact | Address |
|
Name:Michael |
UCD SCHOOL OF BIOMOLECULAR AND BIOMEDICAL SCIENCE, CONWAY INSTITUTE Dublin 4 BELFIELD ÉIRE/IRELAND Region: |
| Tel:+353-1-7166549 | |
| Fax:+353-1-7162157 | |
| E-mail:Contact | |
| URL:http://www.ucd.ie | Organization Type: |
| Organization name:IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE | |
| Administrative contact | Address |
|
Name:Hector |
BIOLOGICAL CHEMISTRY, DIVISION OF BIOMEDICAL SCIENCES, FACULTY OF NATURAL SCIENCE Exhibition Road, South Kensington Campus LONDON UNITED KINGDOM Region:SOUTH EAST (UK) GREATER LONDON |
| Tel:+44-020-75943161 | |
| Fax:+44-020-75943226 | |
| E-mail:Contact | |
| URL:http://www.imperial.ac.uk | Organization Type: |
| Organization name:NETHERLANDS ORGANISATION FOR APPLIED SCIENTIFIC RESEARCH | |
| Administrative contact | Address |
|
Name:Robertus Henricus |
TNO QUALITY OF LIFE, BUSINESS UNIT LIFE SCIENCES FOR FOOD AND PHARMA, PRODUCT GROUP PHYSIOLOGICAL GENOMICS Schoemakerstraat 97 6060 DELFT NEDERLAND Region:ZUID-NEDERLAND LIMBURG (NL) Midden-Limburg |
| Tel:+31-306944545 | |
| Fax:+31-306960264 | |
| E-mail:Contact | |
| URL:http://www.tno.nl | Organization Type: |
| Organization name:EUROPEAN CONSENSUS PLATFORM FOR ALTERNATIVES | |
| Administrative contact | Address |
|
Name:Bernward |
ECOPA Paul Deschanellaan 36-38 BRUSSELS BELGIQUE-BELGIË Region:REG.BRUXELLES-CAP./BRUSSELS HFDST. GEW. |
| Tel:+49-2143043773 | |
| Fax:+49-2143052857 | |
| E-mail:Contact | |
| URL:http://www.ecopa.eu | Organization Type:Other |
| Organization name:INNSBRUCK MEDICAL UNIVERSITY | |
| Administrative contact | Address |
|
Name:Paul |
DEPARTMENT OF PHYSIOLOGY AND MEDICAL PHYSICS, DIVISION OF PHYSIOLOGY, INNSBRUCK MEDICAL UNIVERSITY Christoph-Probst-Platz INNSBRUCK ÖSTERREICH Region:WESTÖSTERREICH TIROL Innsbruck |
| Tel:+435-125073777 | |
| Fax:+435-125072875 | |
| E-mail:Contact | |
| URL:http://www.i-med.ac.at | Organization Type: |
| Organization name:LIVERPOOL JOHN MOORES UNIVERSITY | |
| Administrative contact | Address |
|
Name:Edward |
SCHOOL OF BIOMOLECULAR SCIENCES, LIVERPOOL JOHN MOORES UNIVERSITY Rodney House, 70, Mount Pleasant LIVERPOOL UNITED KINGDOM Region:NORTH WEST (UK) MERSEYSIDE |
| Tel:+1-51-2312187 | |
| Fax:+1-51-2982821 | |
| E-mail:Contact | |
| URL:http://www.ljmu.ac.uk | Organization Type: |
| Organization name:NOVOZYMES AS | |
| Administrative contact | Address |
|
Name:Erwin |
DEPARTMENT OF PHARMA-PROTEIN DEVELOPMENT Krogshoejvej 36 BAGSVAERD DANMARK Region:DANMARK Danmark København og Frederiksberg Kommuner |
| Tel:+45-44424220 | |
| Fax: | |
| E-mail:Contact | |
| URL:http://www.novozymes.com | Organization Type:Industry |
| Organization name:UNILEVER UK CENTRAL RESOURCES LIMITED | |
| Administrative contact | Address |
|
Name:Andrew |
UNILEVER SAFETY ENVIRONMENTAL ASSURANCE CENTRE UNILEVER HOUSE, 100 VICTORIA EMBANKMENT LONDON UNITED KINGDOM Region:SOUTH EAST (UK) GREATER LONDON |
| Tel:+44-1234264828 | |
| Fax:+44-1234222632 | |
| E-mail: | |
| URL:http://seac.unilever.com/home/ | Organization Type:Industry |
| Organization name:ADVANCELL ADVANCED IN VITRO CELL TECHNOLOGIES, S.A. | |
| Administrative contact | Address |
|
Name:Maya |
ADVANCELL ADVANCED IN VITRO CELL TECHNOLOGIES, S.A. C/ Baldiri i Reixach, 10 BARCELONA ESPAÑA Region:ESTE CATALUÑA Barcelona |
| Tel:+34-934037076 | |
| Fax:+34-937891906 | |
| E-mail: | |
| URL:http://www.advancell.net | Organization Type: |
Record control number:85030
