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We have demonstrated the efficacy of glucokinase gene transfection to muscle as a means of increasing glucose disposal in-vitro and in-vivo. Transfer of glucokinase gene in vivo restricted to leg muscle was shown to result in prolonged expression of the protein and enhanced gl...
Programme: FP4-BIOMED 2
Record Number: 26765
Last updated on: 2003-11-27
Une méthode biotechnologique prometteuse pour soigner le diabète
Le diabète sucré désigne un groupe de maladies caractérisé par un taux de glucose sanguin élevé, résultant d'une sécrétion ou d'une action insulinique déficiente, voire des deux. Dans le cas du diabète non insulino-dépendant (DNID), le tissu musculaire joue un rôle clé dans l'...
Programme: FP4-BIOMED 2
Record Number: 80397
Last updated on: 2005-09-18
Available languages: DE, EN, ES, FR, IT
Progressi nel campo della cura del diabete grazie ad un promettente metodo biotecnologico
Il diabete mellito comprende un gruppo di malattie caratterizzate da un elevato tasso ematico di glucosio dovuto a un deficit di attività insulinica (insufficiente produzione o azione dell'insulina, oppure entrambi). In particolare, nel caso del diabete mellito non insulino-di...
Programme: FP4-BIOMED 2
Record Number: 80397
Last updated on: 2005-09-18
Available languages: DE, EN, ES, FR, IT
ID: BMH4972717
Start date: 1997-09-01, End date: 2000-08-31
A major cause of high circulating levels of glucose in non insulin-dependent diabetes mellitus (NIDDM) is the insulin resistance of skeletal muscle. Since muscle is the prime tissue for glucose disposal, the impairment of insulin-stimulated muscle glucose uptake is considered ...
Programme: FP4-BIOMED 2
Record Number: 37771
Last updated on: 2002-04-22
ID: BMH4972640
Start date: 1997-05-01, End date: 2000-04-30
- To apply drug- and concentration-effect modelling to all phases of a clinical drug development program with the specific objective of integrating information obtained from preclinical and clinical studies so that rational choices of dosage regimens can be made at each stage ...
Programme: FP4-BIOMED 2
Record Number: 36417
Last updated on: 2002-04-22
ID: BMH4960254
Start date: 1996-06-01, End date: 1999-05-31
To integrate in vitro tests or models, based on human liver-derived systems. for predicting the metabolism and metabolic interactions of drugs and chemicals which are likely to occur following their exposure in man and compare these with results in vivo.
Programme: FP4-BIOMED 2
Record Number: 32506
Last updated on: 2000-09-21
The systems were characterised systematically for their substrate specificity and kinetics, level of expression of drug metabolising enzymes, at both the RNA and protein level, and their responses to inducing compounds as appropriate. Where necessary, specific reagents, such a...
Programme: FP4-BIOMED 2
Record Number: 23361
Last updated on: 2001-08-09
Prognose des Medikamentenstoffwechsels beschleunigt die Entwicklung von Pharmaka
Im Forschungs- und Entwicklungsprozess für neue Medikamente ist eine genaue Kenntnis der Stoffwechselwege, die die Pharmaka nehmen können, von großer Bedeutung. Der Metabolismus der Medikamente bestimmt ihr pharmakokinetisches Verhalten und ihre Interaktionen mit anderen Hilfs...
Programme: FP4-BIOMED 2
Record Number: 80390
Last updated on: 2005-09-18
Available languages: DE, EN, ES, FR, IT
Prediction of drug metabolism accelerates development of pharmaceuticals
In the research and development process for new drugs, detailed knowledge of the metabolic routes the drugs may follow is of great importance. The metabolism of drugs determines their pharmacokinetic behaviour and their interactions with other compounds. The objective of the c...
Programme: FP4-BIOMED 2
Record Number: 80390
Last updated on: 2005-09-18
Available languages: DE, EN, ES, FR, IT
La predicción del metabolismo de fármacos apremia el desarrollo de sustancias farmacéuticas
En la tarea de investigación y desarrollo de nuevos fármacos, resulta de primera importancia el conocimiento detallado de las rutas metabólicas de los fármacos. El metabolismo de los fármacos determinan su comportamiento farmacocinético y la interacción que mantengan con otros...
Programme: FP4-BIOMED 2
Record Number: 80390
Last updated on: 2005-09-18
Available languages: DE, EN, ES, FR, IT
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