Community Research and Development Information Service - CORDIS

Horizon 2020 project information and now also report summaries are available on CORDIS. All H2020 projects can be downloaded from the EU Open Data Portal .

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A new unified assay for the determination of UDP-glucuronosyltransferase (UGT) activities was developed, using radio-labelled UDPGA and High-Performance Liquid Chromatography. The resolution of [C-14]uridine diphosphate glucuronic acid from radiolabeled glucuronides formed by ...
Programme: FP4-BIOMED 2
Record Number: 26760
Last updated on: 2001-07-30
Injured nerve fibres in the spinal cord are unable to regenerate. Consequently, individuals who have sustained such injuries suffer from lifelong and seriously disabling loss of sensory and/or motor functions. The project has addressed the problem of overcoming spinal cord reg...
Programme: FP4-BIOMED 2
Record Number: 23186
Last updated on: 2003-01-17
The broad pharmacological profile of nociceptin, the endogenous neuropeptide agonist of the ORL1 receptor, points to a plethora of potential therapeutic applications, particularly in the treatment of pain, stress and anxiety. A molecular model of the complex formed between noc...
Programme: FP4-BIOMED 2
Record Number: 26764
Last updated on: 2001-07-30
Screening for ORL1 receptor ligands. A selective and quantitative radio-receptor assay has been set up. This assay is based upon the ability of a compound to compete with equilibrium binding of radiolabelled nociceptin in a crude membrane fraction from recombinant CHO cells ex...
Programme: FP4-BIOMED 2
Record Number: 26763
Last updated on: 2001-07-30
Multiple sclerosis (MS) is a common inflammatory/demyelinating disease of the central nervous system (CNS) in Europe and current treatments are only modestly beneficial. Myelin oligodendrocyte glycoprotein (MOG) is potentially relevant as target autoantigen in MS. It is theref...
Programme: FP4-BIOMED 2
Record Number: 27107
Last updated on: 2003-01-17
Myelin oligodendrocyte glycoprotein (MOG) is potentially relevant as target auto-antigen in MS. It can recruit both an encephalitogenic T cell response and a demyelinating B cell response. It is therefore of interest to explore the genetic regulation of MOG induced experimenta...
Programme: FP4-BIOMED 2
Record Number: 27106
Last updated on: 2003-01-17
The described co-culture test system can be used to reveal the potential oculotoxicity of new drugs which need metabolic activation before they exert toxicity. Most of drugs fall into this category. The possibility to use human primary hepatocytes as activator cells allows thi...
Programme: FP4-BIOMED 2
Record Number: 26758
Last updated on: 2001-07-30
Low-energy laser (He-Ne) irradiation (LELI) was found to promote skeletal muscle regeneration in vivo. LELI has a direct effect on myogenic cells, since the same response (delayed differentiation and enhanced proliferation) was obtained in vitro upon treatment of primary rat s...
Programme: FP4-BIOMED 2
Record Number: 26766
Last updated on: 2001-07-30
The expression of seven sulfotransferase enzymes in E. coli provides the means of producing large quantitites of recombinant enzyme for enzyme kinetic determinations and purification for the production of antibodies. Protocols and methods for the expression of sulfotransferas...
Programme: FP4-BIOMED 2
Record Number: 26755
Last updated on: 2001-07-30
By using the method developed it is possible to determine the rate of methylation catalyzed by the enzyme catechol O-methyltransferase practically for any catechol-type substrate. A new chromatographic catechol O-methyltransferase (COMT) assay based on S-adenosyl-L-[methyl-14...
Programme: FP4-BIOMED 2
Record Number: 26761
Last updated on: 2001-07-30
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