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Horizon 2020 project information and now also report summaries are available on CORDIS. All H2020 projects can be downloaded from the EU Open Data Portal .

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The expression of two human UDP-glucuronosyltransferase isoenzymes in Semliki Forest virus expression system provides the means of producing large quantities of recombinant enzyme for enzyme kinetic determinations. Protocols and methods for the expression of human UDP-glucuro...
Programme: FP4-BIOMED 2
Record Number: 26759
Last updated on: 2001-07-30
The expression of five human UDP-glucuronosyltransferase isoenzymes in V79 cells provides the means of producing large quantities of recombinant enzyme for enzyme kinetic determinations and for the characterisation of antibodies. Protocols and methods for the expression of hu...
Programme: FP4-BIOMED 2
Record Number: 26757
Last updated on: 2001-07-30
The 1-hydroxypyrene UGT method provides a novel tool for quantifying extremely low UGT activities in the human liver as well as in other tissue specimens. This in vitro glucuronidation reaction is preferentially catalyzed by the human recombinant UGT1A6 and UGT1A9 isoforms. On...
Programme: FP4-BIOMED 2
Record Number: 26756
Last updated on: 2001-07-30
Rat hepatocytes have been cultured as primary cultures and incubated in the presence of various catechols. The hepatocytes have the advantage to express the whole set of drug metabolising enzymes, including the UDP-glucuronosyltransferases, sulfotransferases and catechol-O-met...
Programme: FP4-BIOMED 2
Record Number: 26753
Last updated on: 2001-07-30
A new mouse model has been established that is useful as a model for multiple sclerosis. The mouse contains the following genes from humans; the human class II genes DRA and DRB, the human CD4 and a human T cell receptor (TCRA and TCRB) specific for a peptide derived from myel...
Programme: FP4-BIOMED 2
Record Number: 26347
Last updated on: 2003-01-17
The enhancement of endoscopic visualization systems which is important prerequisite in minimally invasive interventions is directed to future endoscope units which offer improved resolution, increased miniaturization, higher automation, better image processing, advanced and au...
Programme: FP4-BIOMED 2
Record Number: 23348
Last updated on: 1999-11-11
We have investigated the molecular genetic basis as well as environmental factors of importance for this variation. The cytochrome P450 enzyme CYP2D6 is polymorphine and there are poor metabolisers who are unable to metabolised antidepressants and neuroleptic drugs. Such patie...
Programme: FP4-BIOMED 2
Record Number: 25929
Last updated on: 2001-03-05
The word anchorage refers, in the biomedical field, to the old dream of the connection between a living organism and prosthesis. The history of joint replacement is governed by the problem of the fixation of the implants. First indicated for older patients only, the increasing...
Programme: FP4-BIOMED 2
Record Number: 23349
Last updated on: 1999-11-11
By transfer of a curative transgene, we have achieved the full phenotypic reversion of primary keratinocytes of patients with a mild form of junctional epidermolysis bullosa (JEB) associated with genetic point mutations in the laminin beta3 gene. These findings confirm the fea...
Programme: FP4-BIOMED 2
Record Number: 26351
Last updated on: 2003-01-17
[REPORT SUMMARY] Amniodistention devices
Although the amnio-insufflator is technically satisfying, its clinical use is hampered by the observation that CO2 affects fetal acid-base status (reference 1). Recent observations have questioned the concern for fetal hypercapnia and acidosis (reference 2), but the research c...
Programme: FP4-BIOMED 2
Record Number: 23307
Last updated on: 1999-11-03
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