Community Research and Development Information Service - CORDIS

Results 1 - 10 of 18
Order by: Results/page:
12 > 
From mesoderm to hematopoietic stem cell commitment: cellular and molecular events occuring during mouse embryonic development
ID: 309361
Start date: 2013-03-01, End date: 2018-02-28
Hematopoietic Stem Cells (HSCs) are at the origin of all blood cells needed throughout life. HSC transplantation is used to treat patients with blood related disorders. However, the number of HSCs available for clinic and research remains limited. The production of large quan...
Programme: FP7-IDEAS-ERC
Record Number: 107035
Last updated on: 2017-08-13
Closing in on missing heritability and immune dysregulation in macular degeneration
ID: 310644
Start date: 2013-01-01, End date: 2017-12-31
Age-related macular degeneration (AMD) is the most common cause of irreversible blindness in the Western world. AMD has a strong genetic component, and it has been estimated that 50% of the heritability of AMD is explained by common variants in the complement system. Currentl...
Programme: FP7-IDEAS-ERC
Record Number: 106206
Last updated on: 2017-05-08
The interaction landscape between microbial colonization and functional genome of the host: a systems biology approach in fungal infections
ID: 310372
Start date: 2013-01-01, End date: 2017-12-31
Fungi such as Candida albicans are ubiquitous colonizers of human skin and mucosa. Fungal pathogens invade the host when host defence is diminished, and the combination of fungal and bacterial colonization modulates mucosal and systemic immune responses. Little is known of th...
Programme: FP7-IDEAS-ERC
Record Number: 105950
Last updated on: 2017-05-08
Regulation of gene expression and cell fate by DNA (hydroxy)methylation
ID: 309384
Start date: 2013-10-01, End date: 2018-09-30
(Hydroxy)methylation of cytosine residues in eukaryotic DNA represents a major means to regulate gene expression during development. These modifications are considered to be epigenetic marks, since they have a profound impact on phenotype, but are inherited from mother to dau...
Programme: FP7-IDEAS-ERC
Record Number: 105899
Last updated on: 2017-05-08
Towards evidence-based genomic medicine: filling the evidence gaps through modelling studies
ID: 310884
Start date: 2014-01-01, End date: 2018-12-31
At increasingly high rate, genome-wide association and whole genome sequencing studies unravel genetic variants implicated in common diseases such as coronary heart disease, cancer, dementia and type 2 diabetes. One of the major promises is that these advances will lead to mo...
Programme: FP7-IDEAS-ERC
Record Number: 111046
Last updated on: 2017-03-13
Full biomechanical characterization of the coronary atherosclerotic plaque: biomechanics meets imaging
ID: 310457
Start date: 2013-05-01, End date: 2019-04-30
Myocardial infarction is responsible for nearly 40% of the mortality in the western world and is mainly triggered by rupture of vulnerable atherosclerotic plaques in the coronary arteries. Biomechanical parameters play a major role in the generation and rupture of vulnerable ...
Programme: FP7-IDEAS-ERC
Record Number: 107424
Last updated on: 2016-12-12
The Origin of Jawed Vertebrates and the Evolution of Morphology in Deep Time
ID: 311092
Start date: 2013-01-01, End date: 2017-12-31
Jawed vertebrates account for more than 99% of modern vertebrate diversity. Collectively, they comprise chondrichthyans (sharks, rays, and chimaeras) and osteichthyans (bony fishes and terrestrial vertebrates, including humans). The anatomy of jawed vertebrates includes a ser...
Programme: FP7-IDEAS-ERC
Record Number: 105578
Last updated on: 2016-10-31
Counteracting psychosis by optimizing interaction
ID: 309767
Start date: 2013-04-01, End date: 2018-03-31
Psychotic disorders are amongst the most severe mental disorders. However, current treatments have failed to reduce disability or change the prospects for recovery for patients with a psychotic disorder. In this project, I will investigate an entirely novel therapy, targeting...
Programme: FP7-IDEAS-ERC
Record Number: 107974
Last updated on: 2016-08-15
The Dynamics of Genome Processing
[PROJECT] DynGenome - The Dynamics of Genome Processing
ID: 312221
Start date: 2013-01-01, End date: 2017-12-31
The vast quantity of information in our genomes must continuously be read out and processed. This is done by proteins, acting either individually or as part of larger protein complexes. How this genome processing operates successfully, given the crowded nature of the DNA trac...
Programme: FP7-IDEAS-ERC
Record Number: 105026
Last updated on: 2016-03-31
Genome-wide identification of factors controlling the telomere damage response and telomere-driven genomic instability
ID: 311565
Start date: 2012-10-01, End date: 2017-09-30
Telomeres are specialized nucleoprotein complexes that protect chromosome ends against recognition as DNA breaks. In somatic cells telomeres shorten every cell division, eventually compromising telomere function. This leads to activation of a DNA damage response that induces ...
Programme: FP7-IDEAS-ERC
Record Number: 105023
Last updated on: 2016-03-31
12 > 
List retrieved on: 2017-11-20
Follow us on: RSS Facebook Twitter YouTube Managed by the EU Publications Office Top