Community Research and Development Information Service - CORDIS

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Neurobiological basis of collective decision making in the human brain
ID: 309865
Start date: 2013-01-01, End date: 2017-12-31
We continually interact with each other & share information to make decisions together as friends, families, committees, juries, interest groups and institutions. The question of how collective decisions are made dates back many centuries and has been vigorously studied in so...
Programme: FP7-IDEAS-ERC
Record Number: 105902
Last updated on: 2016-06-20
Specificity in the ubiquitin system
[PROJECT] UBSPECIFIC - Specificity in the ubiquitin system
ID: 309756
Start date: 2012-10-01, End date: 2017-09-30
Protein ubiquitination is an important posttranslational modification that regulates virtually all cellular processes. Its versatility arises from the ability of ubiquitin to form eight structurally and functionally distinct polymeric chains. It is clear that all chain types ...
Programme: FP7-IDEAS-ERC
Record Number: 105257
Last updated on: 2016-06-20
Protein Misfolding: Prion-like Propagation and Cure. 
Implications for Neurodegenerative Diseases
ID: 309516
Start date: 2013-02-01, End date: 2018-01-31
My long-term goal is to understand, how misfolded proteins, associated with the pathogenesis of most neurodegenerative diseases, propagate in a prion-like manner (i) and to identify strategies that could lead to cure protein misfolding (ii). (i) We have recently discovered th...
Programme: FP7-IDEAS-ERC
Record Number: 105962
Last updated on: 2016-06-20
Alcohol Consumption across the Life-course: Determinants and Consequences
ID: 309337
Start date: 2013-01-01, End date: 2017-12-31
The epidemiology of alcohol use and related health consequences plays a vital role by monitoring populations’ alcohol consumption patterns and problems associated with drinking. Such studies seek to explain mechanisms linking consumption to harm and ultimately to reduce the h...
Programme: FP7-IDEAS-ERC
Record Number: 105371
Last updated on: 2016-06-20
Function and production of secondary metabolites
ID: 311477
Start date: 2013-03-01, End date: 2018-02-28
"Secondary metabolites (SMs) of bacterial origin play a pivotal role in modern therapy of various diseases. Whole-genome sequencing projects have revealed that all SM producing organisms have the capacity to produce many more compounds than reported from the respective strain...
Programme: FP7-IDEAS-ERC
Record Number: 106208
Last updated on: 2016-06-14
The in vivo roles of tRNA modification
ID: 310489
Start date: 2012-12-01, End date: 2017-11-30
tRNA molecules are key in translating the genetic information into a protein sequence and critical for all aspects of cellular metabolism. Interestingly, tRNAs carry a plethora of chemical modifications, thought to regulate their function. Many of these modifications are evol...
Programme: FP7-IDEAS-ERC
Record Number: 105787
Last updated on: 2016-06-13
Cytosine-5 methylated RNAs as stem cell regulators in normal tissues and diseases
ID: 310360
Start date: 2013-02-01, End date: 2018-01-31
Stem cells differentiate into all mammalian tissues and organs during development, and remain present to maintain and replenish tissues throughout life. Stem cells continuously maintain their population (self-renewal) while generating progeny (differentiation). During self-re...
Programme: FP7-IDEAS-ERC
Record Number: 106918
Last updated on: 2016-06-13
Atlas of Cell-Type Specific Nuclear Pore Complex Structures
ID: 309271
Start date: 2013-02-01, End date: 2018-01-31
The nuclear pore complex (NPC) is one of the most intricate components of eukaryotic cells and is assembled from ~30 Nucleoporins (Nups) in an unknown manner. Here I present an experimental result driven hypothesis, namely that the composition of the NPC varies across human c...
Programme: FP7-IDEAS-ERC
Record Number: 106536
Last updated on: 2016-05-09
Epigenetic control and impact of mammalian retrotransposons in pluripotent genomes
ID: 309433
Start date: 2013-07-01, End date: 2018-06-30
Almost half of the human genome is made of Transposable Elements (TEs), whose ongoing activity continually impacts our genome. However, little is known about how the host regulates TEs and their genomic and epigenomic impacts. EpiPluriRetro will advance research in a new grou...
Programme: FP7-IDEAS-ERC
Record Number: 110327
Last updated on: 2016-04-26
Interplays between miRNAs and transcription factors in the determination and maintenance of cell identity
ID: 310510
Start date: 2012-11-01, End date: 2015-10-31
"miRNAs are small RNAs that guide the RNA-induced silencing complex to mRNA targets, destabilizing them and inhibiting their translation. Much has been learned about their involvement in organism development and function, yet some striking puzzles remain. On the one hand it h...
Programme: FP7-IDEAS-ERC
Record Number: 105372
Last updated on: 2016-04-26
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List retrieved on: 2017-11-20
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